Evidence map›Paper›PMID 42249294›Full record

ArticleBMC genomics2026

Genome-wide analysis of the NLR gene family in strawberry reveals a novel immune receptor architecture in Rosaceae.

Alicia Sillers, Mishi V Vachev, Marta Bjornson, Patrick P Edger, Burkhard Steuernagel, Steven J Knapp, Mitchell J Feldmann

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Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Alicia SillersDepartment of Plant Sciences, University of California, Davis, One Shields Ave, Davis, 95616, CA, USA.
Mishi V VachevDepartment of Plant Sciences, University of California, Davis, One Shields Ave, Davis, 95616, CA, USA.
Marta BjornsonDepartment of Plant Sciences, University of California, Davis, One Shields Ave, Davis, 95616, CA, USA.
Patrick P EdgerDepartment of Horticulture, Michigan State University, 220 Trowbridge Rd, East Lansing, 48824, MI, USA.
Burkhard SteuernagelJohn Innes Centre, Norwich Research Park, NR4 7UH, Norwich, UK.
Steven J KnappDepartment of Plant Sciences, University of California, Davis, One Shields Ave, Davis, 95616, CA, USA.
Mitchell J FeldmannDepartment of Plant Sciences, University of California, Davis, One Shields Ave, Davis, 95616, CA, USA. mjfeldmann@ucdavis.edu.

Funding

National Institute of Food and Agriculture 2017-51181-B6833National Science Foundation 2029959
6 · The paper itself

Abstract

backgroundNucleotide-binding leucine-rich-repeat receptors (NLRs) are key components of plant innate immunity. These intracellular proteins specifically recognize pathogen effectors and subsequently activate a defense response. The genes encoding these proteins comprise one of the largest and most diverse gene families in plants. Understanding the various forms and functions of these proteins is imperative to the goal of generating disease resistant crops. This is particularly important for cultivated strawberry, which is heavily impacted by disease.

resultsUsing conserved motifs and functional domains, we identified 827 NLR-encoding genes (NLRs) in the (Fragaria × ananassa) 'FaRR1' genome and categorized them according to their association with the anciently diverged RNL, CNL, and TNL classes. Among these, 45 were newly annotated and 149 were predicted to be full-length. 94 genes exhibited a previously unreported architecture, containing both CNL-specific and TNL-specific sequences. This architecture was supported by full-length transcript data and was found to be present in additional Rosaceous species but not in any non-Rosaceous species examined. Expression analyses revealed that 586 NLRs, including nearly all those with the novel mixed architecture, were differentially expressed following inoculation with at least one of five pathogens.

conclusionsOur genome-wide analysis expands the catalog of NLR genes in cultivated strawberry and uncovers a previously undescribed form of domain organization that may be unique to the Rosaceae family. The results suggest that recombination or domain swapping among N-terminal regions has contributed to NLR diversification in this lineage, providing insight into the evolutionary and functional basis of pathogen recognition in strawberry.

Indexed as

FragariaMultigene FamilyNLR ProteinsPlant ProteinsReceptors, ImmunologicGenome, PlantPhylogenyNLR ProteinsPlant ProteinsReceptors, ImmunologicEffector-triggered immunityNLRNucleotide-binding leucine-rich-repeatResistance genesRosaceaeStrawberry

Identifiers

PMID42249294
PMCPMC13465223

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