Evidence map›Paper›PMID 42249171›Full record

ArticleJournal of neuro-oncology2026

Socioeconomic status and outcomes following spine stereotactic body radiation therapy.

Samuel Adida, Suchet Taori, Amelia Stepniak, Nicole Don, Andrew H Zureick, Serah Choi, John C Flickinger, James C Bayley, Pascal O Zinn, Roberta K Sefcik and 1 more

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Article in Journal of neuro-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Samuel AdidaDepartment of Neurological Surgery, University of Pittsburgh Medical Center, 200 Lothrop St Suite B-400, Pittsburgh, PA, 15213, USA. adidas@upmc.edu.
Suchet TaoriDepartment of Neurological Surgery, University of Pittsburgh Medical Center, 200 Lothrop St Suite B-400, Pittsburgh, PA, 15213, USA.
Amelia StepniakDepartment of Neurological Surgery, University of Pittsburgh Medical Center, 200 Lothrop St Suite B-400, Pittsburgh, PA, 15213, USA.
Nicole DonDepartment of Neurological Surgery, University of Pittsburgh Medical Center, 200 Lothrop St Suite B-400, Pittsburgh, PA, 15213, USA.
Andrew H ZureickDepartment of Radiation Oncology, University of Pittsburgh Medical Center, 5115 Centre Ave, Pittsburgh, PA, 15232, USA.
Serah ChoiDepartment of Radiation Oncology, University of Pittsburgh Medical Center, 5115 Centre Ave, Pittsburgh, PA, 15232, USA.
John C FlickingerDepartment of Radiation Oncology, University of Pittsburgh Medical Center, 5115 Centre Ave, Pittsburgh, PA, 15232, USA.
James C BayleyDepartment of Neurological Surgery, University of Pittsburgh Medical Center, 200 Lothrop St Suite B-400, Pittsburgh, PA, 15213, USA.
Pascal O ZinnDepartment of Neurological Surgery, University of Pittsburgh Medical Center, 200 Lothrop St Suite B-400, Pittsburgh, PA, 15213, USA.
Roberta K SefcikDepartment of Neurosurgery, Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC, 29425, USA.
Peter C GersztenDepartment of Neurological Surgery, University of Pittsburgh Medical Center, 200 Lothrop St Suite B-400, Pittsburgh, PA, 15213, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe Area Deprivation Index (ADI) ranks neighborhoods by adverse social exposome, considering factors related to income, education, employment, and housing quality. This study evaluates the association between socioeconomic status and outcomes following spine stereotactic body radiation therapy (SBRT).

methodsA prospectively maintained database of consecutive patients treated with spine SBRT at a quaternary referral center from 2001 to 2024 was analyzed. Patient addresses were matched to the 2020 ADI to define most advantaged (ADI ≤ 50, 140 patients, 227 metastases) and least advantaged (ADI > 50, 357 patients, 553 metastases) cohorts.

resultsThe distribution of race and ethnicity differed between cohorts, with a greater proportion of Black or African American patients in the least advantaged cohort (2% vs. 6%, P = 0.008). Public insurance coverage was more common in the least advantaged cohort (42% vs. 54%, P = 0.020). There were no differences with respect to age (P = 0.904), sex (P = 0.495), Karnofsky Performance Status (P = 0.930), radioresistant histologies (P = 0.626), systemic disease burden (P = 0.127), prior or adjuvant chemotherapy (P = 0.146) or immunotherapy (P = 0.537), prior open surgical resection (P = 0.196) or conventional external beam radiation therapy (P = 0.268), Bilsky grade (P = 0.191), Spinal Instability Neoplastic Score (P = 0.076), gross tumor volume (P = 0.731), fractionation regimen (P = 0.437), or biologically effective dose (P = 0.499). There was no difference in 6-month, 1-year, 2-year, and 3-year local control (96%, 88%, 85%, and 79% vs. 91%, 83%, 76%, and 73%; P = 0.062) or overall survival (72%, 56%, 37%, and 28% vs. 70%, 55%, 36%, and 28%; P = 0.890). There was no difference in complete or partial pain response (44% vs. 41%, P = 0.196), radiation toxicity (12% vs. 12%, P = 0.876), or vertebral compression fractures (11% vs. 10%, P = 0.637) following treatment. Multivariable Cox proportional hazards analyses did not identify race or ethnicity, insurance coverage, or the ADI as predictors of local control or overall survival.

conclusionRace or ethnicity, insurance coverage, and neighborhood deprivation were not associated with any measured outcomes following spine SBRT. These findings suggest equitable SBRT delivery once patients access care at an academic referral center and reinforce the need to improve referral pathways and insurance authorization for socioeconomically disadvantaged patients.

Indexed as

RadiosurgerySocial ClassSocioeconomic Disparities in HealthSpinal NeoplasmsAgedAged, 80 and overFemaleFollow-Up StudiesHumansLow Socioeconomic StatusMaleMiddle AgedPrognosisProspective StudiesTreatment OutcomeADISBRTSocioeconomic statusSpine oncologySRSStereotactic body radiation therapyStereotactic radiosurgery

Identifiers

PMID42249171

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.