Evidence map›Paper›PMID 42249077›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

Role of submedius thalamus and its interaction with orbitofrontal cortex in incubation of oxycodone craving.

Hongyu Lin, Xiang Luo, Sara Hussain, Nicholas Santiago, Archana Sathiyamoorthy, Jessica Strauch, Xuan Li

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Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Hongyu LinDepartment of Psychology, University of Maryland College Park, College Park, MD, USA.
Xiang LuoDepartment of Psychology, University of Maryland College Park, College Park, MD, USA.
Sara HussainDepartment of Psychology, University of Maryland College Park, College Park, MD, USA.
Nicholas SantiagoDepartment of Psychology, University of Maryland College Park, College Park, MD, USA.
Archana SathiyamoorthyDepartment of Psychology, University of Maryland College Park, College Park, MD, USA.
Jessica StrauchDepartment of Psychology, University of Maryland College Park, College Park, MD, USA.
Xuan LiDepartment of Psychology, University of Maryland College Park, College Park, MD, USA. annali@umd.edu.ORCID http://orcid.org/0000-0002-6737-1223

Funding

U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS130632U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) DA058805
6 · The paper itself

Abstract

A major obstacle in oxycodone addiction treatment is relapse during abstinence. In rats, oxycodone seeking intensifies during abstinence, and orbitofrontal cortex (OFC) is critical for this incubation. Here we studied the role of submedius thalamus (Sub) and its reciprocal connections with OFC in this incubation in male rats. First, using the pharmacological inactivation approach, we examined the causal role of Sub in incubation of oxycodone craving. Next, combining fluorescence-conjugated cholera toxin subunit b (a retrograde tracer) with Fos (a neuronal activity marker), we assessed whether the activation of Sub and OFC connections was associated with incubated oxycodone seeking on abstinence day 15. Using an anatomical disconnection procedure, we then examined the causal role of interactions between Sub and OFC in incubated oxycodone seeking. We also tested the effect of unilateral Sub inactivation on incubated oxycodone seeking, and contralateral disconnection of Sub and OFC on non-incubated oxycodone seeking on abstinence day 1. We found that bilateral Sub inactivation decreased oxycodone seeking on abstinence day 15 but not on day 1, and incubated oxycodone seeking was associated with activation of both Sub→OFC and OFC→Sub projections. Further, both contralateral and ipsilateral disconnection of Sub and OFC decreased incubated oxycodone seeking. Unilateral Sub inactivation had no effect on the total responding during oxycodone seeking but impacted within-session responses. Lastly, contralateral disconnection of Sub and OFC had no effect on non-incubated oxycodone seeking. Together, these results demonstrated a novel role of Sub and its interactions with OFC in incubation of oxycodone craving.

Identifiers

PMID42249077

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.