ArticleScientific reports2026
Human placental extract ameliorates methotrexate-induced nephrotoxicity in albino rats: ultrastructural, biochemical and biophysical studies.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methotrexate (MTX) is a well-known medication for the treatment of different cancer types and autoimmune diseases. The current study target was to measure the capability of human placental extract (HPE) to ameliorate the nephrotoxicity induced by MTX in male albino rats. In the present study, rats were distributed into four groups; a control group (each rat was intraperitoneally injected with 0.5 ml of 0.9% NaCl daily for five days), HPE-treated group (HPE, 10.08 mg/Kg b.w/day, was subcutaneously injected for two weeks), MTX-treated group (MTX, 5 mg/Kg b.w/day, was intraperitoneally injected for five days) and MTX and HPE-treated group (Both MTX and HPE were injected to rats at the same time with the same doses, duration and injection routes in MTX and HPE groups). During the experimental period, clinical observations and body weights of rats were recorded. Rats were dissected after twenty-four hours from the last dose of each group, blood samples were collected for relative blood viscosity measurements and kidneys were also collected for biochemical, ultrastructural and dielectric properties (dielectric constant, dielectric loss and conductivity) investigations. MTX treatment resulted in a highly significant decrease in rat body weights, a highly significant decrease in glutathione (GSH) level and catalase (CAT) activity, a significant decrease in superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and a highly significant increase in the malondialdehyde (MDA) level and relative blood viscosity compared to the control group. Besides, obvious ultrastructural changes and pronounced decrease in the dielectric properties of kidney tissues were noticed. While HPE treatment with MTX improved body weight, biochemical, ultrastructural and biophysical changes comparing to the MTX group. Human placental extract can reduce MTX-induced nephrotoxicity in rats through boosting oxidative stress/anti-oxidant balance as it is rich with essential elements.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.