Evidence map›Paper›PMID 42248990›Full record

ArticleScientific reports2026

Integrating genetic and lifestyle determinants in a risk prediction model for esophageal squamous cell carcinoma in Taiwan.

Chen-Shuan Chung, Yi-Hsun Chen, Ming-Hung Hsu, Chen-Huan Yu, Wen-Lun Wang, Hsiu-Po Wang, Ming-Shiang Wu, Chien-Hung Lee, Che-Hong Chen, I-Chen Wu

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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chen-Shuan ChungDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
Yi-Hsun ChenDivision of Gastroenterology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Ming-Hung HsuDepartment of Internal Medicine, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan.
Chen-Huan YuDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
Wen-Lun WangDepartment of Internal Medicine, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan.
Hsiu-Po WangDivision of Gastroenterology and Hepatology, Department of Internal Medicine, College of Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.
Ming-Shiang WuDivision of Gastroenterology and Hepatology, Department of Internal Medicine, College of Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.
Chien-Hung LeeDepartment of Public Health, College of Health Science, Kaohsiung Medical University, Kaohsiung, Taiwan.
Che-Hong ChenDepartment of Chemical and Systems Biology & Center for Asian Health Research and Education, School of Medicine, Stanford University, Stanford, CA, USA. chehong@stanford.edu.
I-Chen WuDivision of Gastroenterology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. minicawu@gmail.com.

Funding

Kaohsiung Medical University KMU-TB114002National Science and Technology Council NSTC 112-2314-B-037 -084 -MY3Prof. Daria Mochly-Rosen at Stanford University NIH/NIAAA11147
6 · The paper itself

Abstract

Esophageal squamous cell carcinoma (ESCC) in East Asia is markedly male predominant, strongly associated with genetic susceptibility and modifiable lifestyle exposures. We developed and validated a risk appraisal model for ESCC by integrating genetic polymorphisms of two key alcohol-metabolizing enzymes-ADH1B and ALDH2-with major carcinogenic exposures from alcohol, tobacco, and betel quid among men. Genetic and lifestyle data were collected from independent cohorts including only male population across five tertiary centers in Taiwan. The training cohort included 396 ESCC patients and 647 controls, and the validation cohort comprised 256 ESCC patients and 260 controls. Six significant predictors were incorporated into a composite risk score derived from log odds ratios. Using a cutoff value of 5, the model achieved an AUC of 0.91, with 80.30% sensitivity and 87.33% specificity in the training cohort. In the validation cohort, the AUC was 0.96 with sensitivity and specificity of 86.33% and 94.23%, respectively. The positive and negative predictive values were 93.64% and 87.50%, respectively. This integrated model reliably identifies male individuals at high risk of ESCC and may serve as a precision screening tool in high-incidence regions.

Indexed as

Alcohol DehydrogenaseAldehyde Dehydrogenase, MitochondrialEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaLife StyleAgedAlcohol DrinkingCase-Control StudiesFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedPolymorphism, Single NucleotideRisk FactorsTaiwanADH1B protein, humanAlcohol DehydrogenaseAldehyde Dehydrogenase, MitochondrialALDH2 protein, humanADH1BALDH2Esophageal cancerPreventionRisk score

Identifiers

PMID42248990
PMCPMC13482638

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.