ArticleScientific data2026
Single cell transcriptome profiling of peripheral blood mononuclear cells in Guillain-Barré syndrome patients.
Article in Scientific data, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Monocyte-plasma cell communication characterizes treatment-associated peripheral immune remodeling in Guillain-Barré syndrome.Frontiers in immunology · 2026Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Guillain-Barré syndrome (GBS) is an autoimmune disorder characterized by acute peripheral demyelination, leading to progressive muscle weakness and sensory loss. While CD4⁺ T cells and circulating macrophages are implicated in autoimmune neuropathies, the compositional dynamics and activation mechanisms of circulating immune cells remain elusive. Here, we performed single-cell RNA sequencing (scRNA-seq) on peripheral blood mononuclear cells (PBMC) from 3 GBS patients and 2 healthy controls. A total of 51358 cells in the PBMC dataset passed the quality control. In addition, immune cell activation and recruitment were validated using mouse model single-cell datasets and rat transcriptome datasets. We delineate a T-cell differentiation-chemokine secretion axis that operates as a pathogenic hub in inflammatory neuropathy. This data resource provides an indispensable foundation for developing immunomodulatory therapies in Guillain-Barré syndrome.
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