In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
16 authors.
Aline LieberDepartment of Infectious Diseases, Molecular Virology, Center for Integrative Infectious Disease Research (CIID), Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany.ORCID 0009-0007-7448-1141 Oskar StauferDepartment for Cellular Biophysics, Max Planck Institute for Medical Research, Heidelberg, Germany; Institute for Molecular Systems Engineering (IMSE), Heidelberg University, Heidelberg, Germany; Max Planck-Bristol Centre for Minimal Biology, University of Bristol, Bristol, UK.ORCID 0000-0002-8015-3132 Zhaozhi SunDepartment of Infectious Diseases, Molecular Virology, Center for Integrative Infectious Disease Research (CIID), Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany.
Ulrike EngelNikon Imaging Center at Heidelberg University and Centre for Organismal Studies (COS), Heidelberg University, Heidelberg, Germany.ORCID 0000-0002-6953-6845 Nathan MikhaylenkoINM - Leibniz Institute for New Materials, Saarbrücken, Germany.
Kevin JahnkeDepartment for Cellular Biophysics, Max Planck Institute for Medical Research, Heidelberg, Germany; Institute for Molecular Systems Engineering (IMSE), Heidelberg University, Heidelberg, Germany; Max Planck-Bristol Centre for Minimal Biology, University of Bristol, Bristol, UK.ORCID 0000-0001-7311-6993 Katja KoppDepartment of Infectious Diseases, Molecular Virology, Center for Integrative Infectious Disease Research (CIID), Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany.ORCID 0000-0001-8812-8815 Philipp KleinDepartment of Infectious Diseases, Molecular Virology, Center for Integrative Infectious Disease Research (CIID), Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany.
Sarah HofmannBrigham and Women's Hospital, Harvard Medical School, Harvard Initiative for RNA Medicine, Boston, MA, USA.ORCID 0000-0002-6115-5239 Oliver T FacklerDepartment of Infectious Diseases, Integrative Virology, Center for Integrative Infectious Disease Research (CIID), Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany.ORCID 0000-0003-2982-4209 Pavel IvanovBrigham and Women's Hospital, Harvard Medical School, Harvard Initiative for RNA Medicine, Boston, MA, USA.ORCID 0000-0002-7986-7760 Ilia PlatzmanDepartment for Cellular Biophysics, Max Planck Institute for Medical Research, Heidelberg, Germany; Institute for Molecular Systems Engineering (IMSE), Heidelberg University, Heidelberg, Germany; Max Planck-Bristol Centre for Minimal Biology, University of Bristol, Bristol, UK.
Joachim P SpatzDepartment for Cellular Biophysics, Max Planck Institute for Medical Research, Heidelberg, Germany; Institute for Molecular Systems Engineering (IMSE), Heidelberg University, Heidelberg, Germany; Max Planck-Bristol Centre for Minimal Biology, University of Bristol, Bristol, UK.
Alessia RuggieriDepartment of Infectious Diseases, Molecular Virology, Center for Integrative Infectious Disease Research (CIID), Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany. alessia.ruggieri@med.uni-heidelberg.de.ORCID 0000-0001-9981-3308 Funding
Deutsche Forschungsgemeinschaft (German Research Foundation) 240245660 TP13NIH National Institutes of Health R01-GM146997the National Institutes of Health NIH R01-GM126150
6 · The paper itselfAbstract
Stress granules (SGs) are biomolecular condensates that form transiently in the cytosol of mammalian cells in response to stress. Dysregulation of their assembly or disassembly is implicated in human age-related diseases. While phase separation is the key process underlying SG assembly, understanding of their function, composition and regulation in response to physiological stimuli is limited. This knowledge gap reflects the challenge of gaining comprehensive and quantitative insights into the dynamic regulation of the complex composition of SGs at the single-cell level. Here we present an emulsion-based microfluidics method to overcome this limitation. "Cytosolic extracts-in-oil droplets" (CEODs) recreate a confined active cytosolic milieu that undergoes phase separation and SG formation in response to stress under physiological conditions. This approach led to the discovery of seven previously unrecognised SG components involved in signalling pathways. CEODs provide a versatile and cost-effective screening platform for future mechanistic and therapeutic studies.
Indexed as
CytosolLipid DropletsStress GranulesStress, PhysiologicalAnimalsEmulsionsHeLa CellsHumansMicrofluidicsPhase SeparationSignal TransductionEmulsions
Identifiers
PMID42248842
PMCPMC13241516
What OpenQuestion holds
Textmetadata
LicenceCC BY
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