Evidence map›Paper›PMID 42248838›Full record

ArticleNature communications2026

Development of LRRC15-binding disulfide-constrained peptides for PET imaging of cancer-associated fibroblasts.

Benjamin J Tombling, Fei Cai, Timothy J Wendorff, Annie Ogasawara, Herman S Gill, Jeff N Tinianow, Andrew Chang, Aaron T Balana, Lingling Peng, Stephen E Miller and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Benjamin J TomblingDepartment of Early Discovery Biochemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA, USA.
Fei CaiDepartment of Early Discovery Biochemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA, USA.
Timothy J WendorffDepartment of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA, USA.
Annie OgasawaraDepartment of Translational Imaging, Genentech Inc., 1 DNA Way, South San Francisco, CA, USA.
Herman S GillDepartment of Translational Imaging, Genentech Inc., 1 DNA Way, South San Francisco, CA, USA.
Jeff N TinianowDepartment of Translational Imaging, Genentech Inc., 1 DNA Way, South San Francisco, CA, USA.
Andrew ChangDeepSeq.AI Inc., San Francisco, CA, USA.
Aaron T BalanaDepartment of Early Discovery Biochemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA, USA.
Lingling PengDepartment of Early Discovery Biochemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA, USA.
Stephen E MillerDepartment of Early Discovery Biochemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-6988-2465
Benjamin T WaltersDepartment of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-5400-0696
Aaron LictaoDepartment of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA, USA.
Qinying YuDepartment of Drug Metabolism & Pharmacokinetics, Genentech Inc., 1 DNA Way, South San Francisco, CA, USA.
David C DeWittDepartment of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, CA, USA.
Yuehua WeiDepartment of Early Discovery Biochemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA, USA.
Sunny Z WuDepartment of Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-6153-0449
Jawahar SudhamsuDepartment of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-0737-2299
Akshay T KrishnamurtyDepartment of Discovery Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA, USA.
Simon P WilliamsDepartment of Translational Imaging, Genentech Inc., 1 DNA Way, South San Francisco, CA, USA.
Jan MarikDepartment of Translational Imaging, Genentech Inc., 1 DNA Way, South San Francisco, CA, USA.
Yingnan ZhangDepartment of Early Discovery Biochemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA, USA.
Henry R MaunDepartment of Early Discovery Biochemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA, USA. maun.henry@gene.com.ORCID http://orcid.org/0000-0002-4909-6061
Daniel KirchhoferDepartment of Early Discovery Biochemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA, USA. kirchhofer.daniel@gene.com.

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Aina E. Cohen, KEITH O HODGSON · 2020 to 2026
$43.3M
User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Gregory L Hura · 2017 to 2026
$28.6M
NIGMS NIH HHS P30 GM124169NIGMS NIH HHS P30 GM133894
6 · The paper itself

Abstract

Leucine-rich-repeat-containing protein 15 (LRRC15) is selectively expressed on cancer-associated fibroblasts (CAFs) and constitutes a promising biomarker for imaging the tumor microenvironment. Using a combinatorial library approach, assisted by machine learning, we developed disulfide-constrained peptides (DCPs), notably ML-YSD-07 and ML-PD-03, that demonstrate subnanomolar affinities for murine LRRC15 (muLRRC15) and specifically localize onto muLRRC15-expressing fibroblasts. PET imaging with

Indexed as

Cancer-Associated FibroblastsDisulfidesPancreatic NeoplasmsPeptidesPositron-Emission TomographyAnimalsCell Line, TumorCrystallography, X-RayHumansMiceProtein BindingTumor MicroenvironmentDisulfidesPeptides

Identifiers

PMID42248838
PMCPMC13350978

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.