Evidence map›Paper›PMID 42248789›Full record

ReviewTrends in microbiology2026

The bacterial march toward symbiosis: on-ramps and off-ramps.

Marjolein Bruijning, Andrew H Moeller, Gavriela Carver, Mohamed S Donia, Britt Koskella, Prerna Singh, C Jessica E Metcalf

Abstract readReview
In one paragraph

Review in Trends in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marjolein BruijningInstitute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, The Netherlands. Electronic address: m.bruijning@uva.nl.
Andrew H MoellerDepartment of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA.
Gavriela CarverDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Mohamed S DoniaDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Britt KoskellaDepartment of Integrative Biology, University of California, Berkeley, Berkeley, CA, USA.
Prerna SinghDepartment of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA; Evolutionary and Integrative Ecology, Leibniz Institute of Freshwater Ecology and Inland Fisheries, Berlin, Germany.
C Jessica E MetcalfDepartment of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA.

Funding

Uncovering the modes and genetics of gut bacterial transmissionR35GM138284 · NIGMS · PRINCETON UNIVERSITY · PI Andrew Moeller · 2020 to 2026
$2.4M
The genomics and consequences of gut bacterial adaptation to high-fat dietsR01DK139214 · NIDDK · PRINCETON UNIVERSITY · PI Andrew Moeller · 2024 to 2026
$1.3M
NIDDK NIH HHS R01 DK139214NIGMS NIH HHS R35 GM138284
6 · The paper itself

Abstract

Host-associated bacteria are found across the tree of life. In this opinion article, we propose that population genetics theory can be used to probe the conditions that form the path toward such symbioses. We illustrate how mutation-selection models generate insights into the maintenance of a symbiont under transmission between generations and from the environment. We outline how basic features of host population size and life history shape the fixation of a heritable symbiont in a host population, suggesting elevated fixation probabilities in long-lived hosts. Finally, whenever the fitness effects of the symbiont vary over time, reduced efficiency of selection increases the fixation of a deleterious symbiont. Our predictions of the properties of hosts, symbionts, and their ecological contexts that impact symbiont establishment frame expectations across systems.

Indexed as

BacteriaBacterial Physiological PhenomenaSymbiosisAnimalsGenetics, PopulationMutationSelection, Geneticfixationlife historymutation-selection balanceobligate symbiontpopulation geneticsvertical transmission

Identifiers

PMID42248789
PMCPMC13338954

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.