Evidence map›Paper›PMID 42248772›Full record

ReviewTrends in neurosciences2026

Cognitive functions of the GPe.

Kyle O'Berry, Aryn H Gittis

Abstract readReview
In one paragraph

Review in Trends in neurosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kyle O'BerryDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, USA.
Aryn H GittisDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, USA; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA, USA. Electronic address: agittis@cmu.edu.

Funding

Circuit-Inspired Strategies to Restore Basal Ganglia Function in Mouse Models of Parkinson’s DiseaseR35NS132213 · NINDS · CARNEGIE-MELLON UNIVERSITY · PI Aryn Hilary Gittis · 2023 to 2026
$2.8M
The Behavioral Brain (B2) Research Training ProgramT32GM142630 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Julie A Fiez, MATTHEW A SMITH · 2022 to 2026
$1.8M
NIGMS NIH HHS T32 GM142630NINDS NIH HHS R35 NS132213
6 · The paper itself

Abstract

The globus pallidus externus (GPe) is a central nucleus in the basal ganglia. Although traditionally defined as a component of the basal ganglia's motor circuit, converging evidence from humans, rodents, and non-human primates has established the GPe as a key contributor to the cognitive control of behavior. In this role, the GPe dynamically regulates goal-directed behavior in response to changing environmental demands. In this review, we highlight recent studies demonstrating that the GPe encodes cue and action values, supports behavioral flexibility, and modulates attention, behavioral inhibition, and habit formation. The picture that emerges is of a nucleus that aligns behavior to internal goals by constraining, updating, and optimizing ongoing actions.

Indexed as

CognitionGlobus PallidusAnimalsAttentionCognitive FlexibilityHumansarousalattentioncognitive flexibilityhabitual behaviormotor controlvalue

Identifiers

PMID42248772
PMCPMC13343372

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.