ReviewChemphyschem : a European journal of chemical physics and physical chemistry2026
DNA-Binding Properties of Iridium(III) Complexes Encompassing Design, Function and Biophysical Assessments.
Review in Chemphyschem : a European journal of chemical physics and physical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The increasingly diverse biological applications of iridium(III) complexes, from luminescent cellular imaging agents to therapeutic and prospective theranostics, has been enabled by a combination of imaginative ligand design and tunable (photo)physical properties. Within this biological context, it is crucial to understand how molecular probes interact with biological substrates and macromolecules. This review focuses upon the structural diversity of DNA-binding metal complexes based upon iridium(III), the general workflow used to interrogate these interactions with DNA, and critically analyses the relationship between complex structure and functionality.
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