Evidence map›Paper›PMID 42248450›Full record

ArticleThe Journal of biological chemistry2026

Conserved residues in the Gα interface show subtype specificity in Gβγ coupling.

Wenyuan Wei, H Dalton Taylor, Ning Ma, Andrei S Rodin, Sergio Branciamore, Henrik G Dohlman, Nagarajan Vaidehi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Wenyuan WeiDepartment of Computational & Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, California, USA; Irell and Manella Graduate School of Biological Science, Beckman Research Institute of the City of Hope, Duarte, California, USA.
H Dalton TaylorDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Ning MaDepartment of Computational & Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, California, USA.
Andrei S RodinDepartment of Computational & Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, California, USA; Irell and Manella Graduate School of Biological Science, Beckman Research Institute of the City of Hope, Duarte, California, USA.
Sergio BranciamoreDepartment of Computational & Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, California, USA; Irell and Manella Graduate School of Biological Science, Beckman Research Institute of the City of Hope, Duarte, California, USA.
Henrik G DohlmanDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Electronic address: hdohlman@med.unc.edu.
Nagarajan VaidehiDepartment of Computational & Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, California, USA; Irell and Manella Graduate School of Biological Science, Beckman Research Institute of the City of Hope, Duarte, California, USA. Electronic address: NVaidehi@coh.org.

Funding

Negative and positive feedback in cell signalingR35GM118105 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Henrik G. Dohlman · 2016 to 2026
$6.6M
An integrated toolkit combining computational systems biology techniques with molecular dynamics simulations to delineate functionality of GPCRsR01LM013876 · NLM · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI RODIN, ANDREI, VAIDEHI, NAGARAJAN · 2022 to 2025
$1.5M
Emergent role of allostery on function of GPCRs and Trimeric G proteinsR35GM156498 · NIGMS · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Nagarajan Vaidehi · 2025 to 2026
$890k
Scalable Bayesian Network analysis of multimodal FACS and SUMOylation data, with generalization to other big mixed biological datasetsR01LM013138 · NLM · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI RODIN, ANDREI · 2020 to 2022
$776k
NIGMS NIH HHS R35 GM118105NIGMS NIH HHS R35 GM156498NLM NIH HHS R01 LM013138NLM NIH HHS R01 LM013876
6 · The paper itself

Abstract

Although the structural basis of selective interaction of G-proteins and G protein-coupled receptors (GPCRs) is well-characterized, the mechanisms underlying selective interactions between distinct Gα subtypes (Gα

Indexed as

GTP-Binding Protein alpha SubunitsGTP-Binding Protein beta SubunitsGTP-Binding Protein gamma SubunitsBayes TheoremConserved SequenceHumansMolecular Dynamics SimulationGTP-Binding Protein alpha SubunitsGTP-Binding Protein beta SubunitsGTP-Binding Protein gamma SubunitsBayesian Network Modelbioluminescent resonance energy transferheterotrimeric G proteinsmolecular dynamics simulationssite-directed mutagenesis

Identifiers

PMID42248450
PMCPMC13355190

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.