Evidence map›Paper›PMID 42247517›Full record

ArticleScience advances2026

A plant pathogen effector blocks stepwise assembly of a helper NLR resistosome.

Benjamin A Seager, Adeline Harant, Mauricio P Contreras, Liang-Yu Hou, Chih Hang Wu, Sophien Kamoun, Jogi Madhuprakash

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Diversification and deployment of PRR and NLR immune receptors in potato.The Plant journal : for cell and molecular biology · 2026
    Review
  3. Article
  4. Plant NLRs are getting into higher-order architectures.The Plant journal : for cell and molecular biology · 2026
    Review
  5. Molecular mechanisms of plant NLR activation and signalling.The Plant journal : for cell and molecular biology · 2026
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Benjamin A SeagerThe Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK.ORCID 0009-0000-3161-1849
Adeline HarantThe Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK.ORCID 0000-0001-7636-4917
Mauricio P ContrerasThe Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK.ORCID 0000-0001-6002-0730
Liang-Yu HouInstitute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan.ORCID 0000-0002-8434-5545
Chih Hang WuInstitute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan.ORCID 0000-0003-1616-1872
Sophien KamounThe Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK.ORCID 0000-0002-0290-0315
Jogi MadhuprakashThe Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK.ORCID 0000-0001-6491-0423

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Helper NLRs function as central nodes in plant immune networks. Upon activation, they oligomerize into inflammasome-like resistosomes to initiate immune signaling, yet the dynamics of resistosome assembly remain poorly understood. Here, we show that the virulence effector AVRcap1b from the Irish potato famine pathogen

Indexed as

Host-Pathogen InteractionsNLR ProteinsPhytophthora infestansPlant DiseasesPlant ProteinsSolanum lycopersicumCryoelectron MicroscopyInnate Immunity RecognitionPlant ImmunityNLR ProteinsPlant Proteins

Identifiers

PMID42247517
PMCPMC13240224

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.