Evidence map›Paper›PMID 42247491›Full record

ArticleScience advances2026

A minimal transcription factor network is sufficient to drive paclitaxel biosynthesis.

Qiaona Pan, Marisol Ochoa-Villarreal, Susan Howat, Rabia Amir, Zejun Yan, Christopher E French, Gary J Loake, Beimi Cui

RetractedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Editorial expression of concern.Science advances · 2026
    Article
  2. Recent advances inFrontiers in plant science · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Qiaona PanSchool of Horticulture and Landscape Architecture, Yangzhou University, Yangzhou, Jiangsu 225009, China.ORCID 0000-0002-9142-1905
Marisol Ochoa-VillarrealInstitute of Molecular Plant Sciences, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, UK.
Susan HowatInstitute of Molecular Plant Sciences, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, UK.
Rabia AmirInstitute of Molecular Plant Sciences, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, UK.ORCID 0000-0001-7032-5888
Zejun YanInstitute of Molecular Plant Sciences, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, UK.
Christopher E FrenchCentre for Engineering Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, UK.ORCID 0000-0003-0700-5675
Gary J LoakeInstitute of Molecular Plant Sciences, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, UK.ORCID 0000-0002-7989-9180
Beimi CuiSchool of Horticulture and Landscape Architecture, Yangzhou University, Yangzhou, Jiangsu 225009, China.ORCID 0000-0002-4901-1988

Funding

Wellcome Trust
6 · The paper itself

Abstract

The supply of the anticancer drug paclitaxel is limited by its low natural abundance and complex chemical structure. We previously reported the development of a cultured

Indexed as

Gene Regulatory NetworksPaclitaxelTaxusTranscription FactorsAcetatesAlkaloidsCyclopentanesGene Expression Regulation, PlantMeristemOxylipinsPlant ProteinsPlants, Genetically ModifiedTaxoidsAcetatesAlkaloidsbaccatin IIICyclopentanesmethyl jasmonateOxylipinsPaclitaxelPlant ProteinsTaxoidsTranscription Factors

Identifiers

PMID42247491
PMCPMC13240184

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.