Evidence map›Paper›PMID 42247465›Full record

ArticlePLoS neglected tropical diseases2026

Development of a deep learning based framework for classification of Indian venomous snakes integrated with explainable artificial intelligence for primary and emergency care providers.

Ikhlaas Ifthikar Abusayeed Manna, Usha Wagle, Badhrinarayanan Balaji, Vrinda Lath, Niranjana Sampathila, Sudhakara Upadya P, Freston Marc Sirur

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Article in PLoS neglected tropical diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Ikhlaas Ifthikar Abusayeed MannaManipal School of Information Sciences, Manipal Academy of Higher Education, Manipal, India.
Usha WagleDepartment of Emergency Medical Technology, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, India.
Badhrinarayanan BalajiManipal School of Information Sciences, Manipal Academy of Higher Education, Manipal, India.
Vrinda LathDepartment of Emergency Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Niranjana SampathilaManipal Institute of Technology, Manipal Academy of Higher Education, Manipal, India.
Sudhakara Upadya PManipal School of Information Sciences, Manipal Academy of Higher Education, Manipal, India.
Freston Marc SirurDepartment of Emergency Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.ORCID https://orcid.org/0000-0002-8095-2516

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSnakebite envenoming is a significant global health crisis that has been long neglected as a global health priority. It is a huge problem for rural communities of low and middle-income countries, India accounts for the largest proportion of snakebite deaths globally. Timely identification of venomous snakebite and its syndromic pattern is essential for effective administration of antivenom and supportive treatment. Expert identification of snake species and syndromes is not always available in peripheral healthcare settings. This leads to delays, unnecessary referrals, or improper treatment choices. Additionally, diverse snake species distribution and venom variations across regions pose challenges. AI-powered image classification methods can help overcome these barriers. We propose a clinically oriented deep learning pipeline for binary classification of venomous and non-venomous snake species of India using real-world imagery data. This pipeline would serve as a baseline step towards aiding snakebite management at peripheral healthcare setups with scarce resources.

methodsThe selected dataset consisted of 20 medically important Indian species. MobileViT-S, ConvNeXt-Tiny, EfficientNet-V2-S and ResNeXt-50 (32 × 4d) were trained under same conditions for comparison of results. Model interpretability was evaluated using Grad-CAM ++ to ensure that classification was not performed based on background but on features like head shape and stripes present on body. For reliable implementation we connected it to a web interface with human in loop expert verification. Experts can confirm or override predictions in real time.

resultsAmong the evaluated architectures, ResNeXt-50 (32 × 4d) showed the most reliable and consistent performance in classifying venomous and non-venomous snakes. It achieved the highest test accuracy, sensitivity, specificity, and F1-score. The model also had strong discriminative ability, with a ROC-AUC of 0.9950 and PR-AUC of 0.9959. These results indicate dependable performance in safety-critical screening situations. Grad-CAM++ visualizations confirmed that predictions were based on anatomically relevant features, especially in the head and body contour areas. This supports model interpretability and reduces background bias.

conclusionsAlthough the dataset size and single-institution source limit how widely the results can be applied, the proposed framework shows that it's possible to create a clinically oriented, ready-to-use deep learning system for snakebite triage support. This system is intended as a scalable tool to help rural healthcare workers, emergency responders, and telemedicine platforms in areas where snakebites are common.

Indexed as

Artificial IntelligenceDeep LearningSnake BitesVenomous SnakesAnimalsAntiveninsClassification AlgorithmsHumansIndiaAntivenins

Identifiers

PMID42247465
PMCPMC13271475

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