ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026
In Vitro Biological Activities of Piper corcovadensis C.DC.: Antioxidant, Antineoplastic-Related and Antibacterial Effects.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Oxidative stress, caused by excessive reactive oxygen (ROS) and nitrogen species (NOX), is linked to degenerative, inflammatory, and cancer-related conditions. Piper corcovadensis, a South American native plant, is recognized for its bioactive compounds. This study investigated the total phenolic content (TPC) by the Folin-Ciocalteu method, antioxidant activity (AA), cytotoxicity, and antimicrobial and anti-inflammatory effects of its extract. AA was determined by the ABTS, DPPH, and FRAP assays. Cytotoxicity was evaluated on SK-MEL-28 melanoma cells through the MTT assay. Oxidative stress biomarkers (ROS, NOX), protein thiols (PSH), and non-protein thiols (NPSH) and inflammatory mediators (NLRP3, IL-6, TNF) were analyzed by RT-qPCR at 50, 500, and 5000 μg mL
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