Evidence map›Paper›PMID 42247157›Full record

ReviewGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026

Chromovitrectomy: current evidence, emerging technologies, and practical applications in vitreoretinal surgery.

Federico Giannuzzi, Lorenzo Hu, Mattia Cusato, Matteo Mario Carlà, Emanuele Crincoli, Federico Maragno, Valentina Cestrone, Umberto De Vico, Stanislao Rizzo

Abstract readReview
In one paragraph

Review in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Federico Giannuzzi *Ophthalmology Unit, "Fondazione Policlinico Universitario A. Gemelli, IRCCS", Largo A. Gemelli, 8, Rome, Italy.
Lorenzo Hu *Ophthalmology Unit, "Fondazione Policlinico Universitario A. Gemelli, IRCCS", Largo A. Gemelli, 8, Rome, Italy. lorenzo.hu14@gmail.com.
Mattia CusatoOphthalmology Unit, "Fondazione Policlinico Universitario A. Gemelli, IRCCS", Largo A. Gemelli, 8, Rome, Italy.
Matteo Mario CarlàDepartment of Ophthalmology, Hopital Fondation Adolphe De Rothschild, Paris, France.
Emanuele CrincoliUniversità Cattolica del Sacro Cuore, Rome, Italy.
Federico MaragnoOphthalmology Unit, "Fondazione Policlinico Universitario A. Gemelli, IRCCS", Largo A. Gemelli, 8, Rome, Italy.
Valentina CestroneOphthalmology Unit, "Fondazione Policlinico Universitario A. Gemelli, IRCCS", Largo A. Gemelli, 8, Rome, Italy.
Umberto De Vico *Ophthalmology Unit, "Fondazione Policlinico Universitario A. Gemelli, IRCCS", Largo A. Gemelli, 8, Rome, Italy.
Stanislao Rizzo *Ophthalmology Unit, "Fondazione Policlinico Universitario A. Gemelli, IRCCS", Largo A. Gemelli, 8, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chromovitrectomy has revolutionized vitreoretinal surgery by enabling the visualization of nearly transparent intraocular structures. This review evaluates the clinical utility of key vital dyes, such as brilliant blue G, trypan blue, indocyanine green, and triamcinolone acetonide, focusing on their physicochemical properties, staining affinities, and safety profiles. Recent advancements in dye formulation, including high-density and multi-component preparations, have improved tissue selectivity and surgical handling. These pharmacological innovations are now complemented by digital visualization technologies, such as 3D heads-up displays and customizable spectral filtering, which enhance contrast perception and ergonomics. We further discuss specialized surgical strategies for identifying occult retinal breaks and sequential staining techniques, while addressing critical concerns regarding phototoxicity and macular protection. As the field moves toward integrating intraoperative OCT and artificial intelligence, chromovitrectomy remains a dynamic cornerstone of posterior segment surgery. Understanding the synergy between novel biocompatible agents and digital platforms is essential for optimizing surgical precision and patient outcomes.

Indexed as

Coloring AgentsRetinal DiseasesStaining and LabelingVitrectomyVitreoretinal SurgeryVitreous BodyHumansColoring AgentsBrilliant blue GChromovitrectomyDigital visualizationInternal limiting membranePhototoxicityTrypan blueVital dyes

Identifiers

PMID42247157
PMCPMC13635042

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.