ArticleEuropean radiology experimental2026
Whole anterior visual pathway segmentation from high-resolution MRI using artificial intelligence.
Article in European radiology experimental, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveManual segmentation of the whole anterior visual pathway (aVP) from high-resolution magnetic resonance imaging (MRI) is time-consuming and prone to inter-rater variability. We developed and validated a fully automated deep learning framework, "aVP-seg," to perform rapid, multiclass segmentation of the optic nerves, chiasm, and optic tracts in healthy volunteers and multiple sclerosis (MS) patients. MATERIALS AND
methodsWe developed and validated a cascaded two-stage three-dimensional convolutional neural network (principal segmentation + refinement) for automated multiclass segmentation of the aVP from 0.6-mm isotropic three-dimensional constructive interference in steady state (CISS) MRI. The model was trained and evaluated in 34 healthy controls and 46 MS patients. Ground truth was derived from manual segmentations by two expert radiologists. Spatial agreement metrics included Dice similarity coefficient (DSC), 95th percentile Hausdorff distance (HD95), and volumetric similarity.
resultsAgreement with the ground truth for the whole aVP was high (DSC 0.86 ± 0.03, mean ± standard deviation; 95% confidence interval (CI) 0.85-0.86). Boundary alignment was strong (HD95 1.18 mm ± 0.54; 95% CI 1.06-1.30) and volumetric similarity was high (0.96 ± 0.04; 95% CI 0.95-0.97). Accuracy was consistent for the left and right optic nerves (DSC 0.85-0.86 ± 0.05-0.04) and chiasm (DSC 0.83 ± 0.09), but lower for the left and right optic tracts (DSC 0.74-0.75 ± 0.07-0.07).
conclusionThe aVP-seg provided accurate, automated multiclass segmentation of the whole aVP from high-resolution CISS MRI. This tool may standardize and accelerate the extraction of quantitative biomarkers of aVP integrity in neuro-ophthalmic conditions. RELEVANCE STATEMENT: Automated multiclass segmentation of the entire anterior visual pathway enables standardized and reproducible preparation of MRI data for quantitative analysis. This approach facilitates future assessment of optic pathway involvement in MS and other neuro-ophthalmic disorders. KEY POINTS: aVP-seg enabled fully automated segmentation of the entire anterior visual pathway from high-resolution CISS MRI data. Automated segmentation reduces processing time and operator-dependent variability. aVP-seg shows robust performance across both healthy subjects and MS patients.
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