Evidence map›Paper›PMID 42247028›Full record

ArticleMolecular neurobiology2026

Neurobehavioral Impacts of the Autism Risk Gene, WAC: Studies Involving C. elegans and Mice.

Napissara Boonpraman, Da-Woon Kim, Elena Tislerics, Janki Barot, Dariangelly Pacheco-Cruz, Nathan C Kuhn, Daniel Vogt, Shreesh Raj Sammi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Napissara Boonpraman *Department of Translational Neuroscience, College of Human Medicine, Grand Rapids Research Center, Michigan State University, 400 Monroe Ave NW, Grand Rapids, MI, 49503, USA.
Da-Woon Kim *Department of Translational Neuroscience, College of Human Medicine, Grand Rapids Research Center, Michigan State University, 400 Monroe Ave NW, Grand Rapids, MI, 49503, USA.
Elena TislericsDepartment of Translational Neuroscience, College of Human Medicine, Grand Rapids Research Center, Michigan State University, 400 Monroe Ave NW, Grand Rapids, MI, 49503, USA.
Janki BarotDepartment of Translational Neuroscience, College of Human Medicine, Grand Rapids Research Center, Michigan State University, 400 Monroe Ave NW, Grand Rapids, MI, 49503, USA.
Dariangelly Pacheco-CruzDepartment of Neuroscience (Neuroscience Program), Michigan State University, East Lansing, MI, 48824, USA.
Nathan C KuhnDepartment of Translational Neuroscience, College of Human Medicine, Grand Rapids Research Center, Michigan State University, 400 Monroe Ave NW, Grand Rapids, MI, 49503, USA.
Daniel VogtDepartment of Neuroscience (Neuroscience Program), Michigan State University, East Lansing, MI, 48824, USA. vogtdan2@msu.edu.
Shreesh Raj SammiDepartment of Translational Neuroscience, College of Human Medicine, Grand Rapids Research Center, Michigan State University, 400 Monroe Ave NW, Grand Rapids, MI, 49503, USA. sammishr@msu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by a broad spectrum of behavioral impairments. While multiple genetic and environmental factors are attributed to its cause, biological underpinnings are still poorly understood. The WAC gene has been primarily linked with DeSanto-Shinawi syndrome, a rare neurodevelopmental disorder. Due to overlapping manifestations, studies on WAC gene and its potential role in ASD have recently gained traction. This study elucidates effects of WAC deletion and characterizes the findings and mechanisms vis-à-vis relevant neural aberrations in ASD. Mutant Caenorhabditis elegans (wac-1.1

Indexed as

Autistic DisorderBehavior, AnimalCaenorhabditis elegansCaenorhabditis elegans ProteinsGenetic Predisposition to DiseaseAcetylcholineAcetylcholinesterasealpha7 Nicotinic Acetylcholine ReceptorAnimalsDopamineMaleMiceMice, Inbred C57BLReceptors, NicotinicAcetylcholineAcetylcholinesterasealpha7 Nicotinic Acetylcholine ReceptorCaenorhabditis elegans ProteinsDopamineReceptors, NicotinicAutism spectrum disorder (ASD)C. elegansCholinergic signalingCHRNA7WAC gene

Identifiers

PMID42247028
PMCPMC13241405

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.