Evidence map›Paper›PMID 42246990›Full record

ArticleMikrochimica acta2026

One-pot fabrication and characterization of ZnO nanoflowers using Zanthoxylum simulans and evaluating their biomedical claims.

Divya Karthick Rajan, Durairaj Karthick Rajan, Hao Li, Wang Yang, Jinzheng Wu, Shumiao Zhang, Hao Jiang, Shubing Zhang

Abstract read
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Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Divya Karthick RajanDepartment of Cell Biology, School of Life Sciences, Central South University, Changsha, Hunan, 410013, P.R. China.
Durairaj Karthick RajanDepartment of Cell Biology, School of Life Sciences, Central South University, Changsha, Hunan, 410013, P.R. China.
Hao LiDepartment of Cell Biology, School of Life Sciences, Central South University, Changsha, Hunan, 410013, P.R. China.
Wang YangDepartment of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410013, P.R. China.
Jinzheng WuDepartment of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410013, P.R. China.
Shumiao ZhangBeijing Milu Ecological Research Center, Beijing, 100076, P.R. China.
Hao JiangDepartment of Biomedical Informatics, School of Life Sciences, Central South University, Changsha, Hunan, 410013, P.R. China. jianhao1209@csu.edu.cn.
Shubing ZhangDepartment of Cell Biology, School of Life Sciences, Central South University, Changsha, Hunan, 410013, P.R. China. shubingzhang@csu.edu.cn.

Funding

China Postdoctoral Science Foundation (2025M782323)Natural Science Foundation of Hunan Province of China (2025JJ80166)
6 · The paper itself

Abstract

Novel zinc oxide nanoflowers (ZnO NFs) were synthesized using the aqueous extract of Zanthoxylum simulans. The green synthesized Zs-ZnO NFs were characterized using FT-IR, XPS, XRD, HR-TEM, EDAX, DLS, and zeta potential (ZP) analysis to confirm the physicochemical properties. HR-TEM analysis exposed the flower-like morphology with uniform size. The XPS analysis exposed the elements present in the Zs-ZnO NFs. Further, the Zn element exhibited two binding energy peaks at 1021.41 and 1044.50 eV. The purity of Zs-ZnO NFs was confirmed using EDAX analysis. The Zs-ZnO NFs displayed bactericidal properties against the tested pathogens. To evaluate the effectiveness of Zs-ZnO NFs against dental pathogens via MIC, antibacterial, biofilm ring formation, and TTC assays were performed. A concentration-dependent biofilm inhibition was also observed against Staphylococcus aureus and Streptococcus mutans upon treatment with Zs-ZnO NFs, and it was confirmed using a 2.5D fluorescence imaging technique. A 100 µg/mL of Zs-ZnO NFs treatment displayed bacterial cell death, which was confirmed via dual staining. Furthermore, Zs-ZnO NFs induced protein leakage was observed upon treatment with 100 µg/mL concentration against the pathogens. Cytotoxicity of Zs-ZnO NFs was confirmed using HUVECs cells. Overall, the synthesized Zs-ZnO NFs exhibits efficient bactericidal, antibiofilm and biocompatible properties.

Indexed as

Anti-Bacterial AgentsNanostructuresPlant ExtractsZanthoxylumZinc OxideBiofilmsHumansMicrobial Sensitivity TestsStaphylococcus aureusStreptococcus mutansAnti-Bacterial AgentsPlant ExtractsZinc OxideAntibacterialAnti-biofilmBiocompatibilityDental pathogensNanoflowersZanthoxylum simulans

Identifiers

PMID42246990

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.