Evidence map›Paper›PMID 42246934›Full record

ArticleRedox report : communications in free radical research2026

The cysteine metabolic regulation through CSE-transsulfuration pathway is essential in iron-induced oxidative damage of heart.

Yong Zhang, Yijun Xin, Jie Zhou, Guang Yang, Siying Li

Abstract read
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Article in Redox report : communications in free radical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yong ZhangMetabolism and Disease Research Center, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.
Yijun XinMetabolism and Disease Research Center, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.
Jie ZhouMetabolism and Disease Research Center, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.
Guang YangDepartment of Sports Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Siying LiMetabolism and Disease Research Center, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.ORCID 0000-0001-6906-8394

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesIron overload (IO) cardiomyopathy is a major cause of mortality in patients with iron overload disorders. This study investigates the role of cystathionine

methodsWe investigated the effects of CSE on oxidative stress, metabolic dysregulation, and cardiac remodeling using

resultsGenetic deletion of

conclusionThese findings demonstrate that the CSE-transsulfuration pathway serves as a crucial regulator of cysteine metabolism and antioxidant signaling in cardiomyocytes, presenting a potential therapeutic target in iron-induced cardiomyopathy.

Indexed as

Cystathionine gamma-LyaseCysteineIronOxidative StressAnimalsHydrogen SulfideIron OverloadMaleMiceMice, Inbred C57BLMyocardiumMyocytes, CardiacNF-E2-Related Factor 2Reactive Oxygen SpeciesSignal TransductionCystathionine gamma-LyaseCysteineHydrogen SulfideIronNF-E2-Related Factor 2Reactive Oxygen SpeciesCardiac injurycystathionine γ-lyasecysteineGPX4Iron overloadNrf2oxidative stressSLC7A11

Identifiers

PMID42246934
PMCPMC13244509

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.