ArticleJACC. Asia2026
Right Ventricular-to-Pulmonary Artery Uncoupling Following Transcatheter Edge-to-Edge Repair in Ventricular Functional Mitral Regurgitation.
Article in JACC. Asia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- RV-PA Uncoupling: Understanding the Continuum of a Failing Heart.JACC. Asia · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prognostic value of right ventricular-pulmonary artery (RV-PA) coupling in patients with ventricular functional mitral regurgitation (FMR) undergoing mitral transcatheter edge-to-edge repair (M-TEER) is unclear.
objectivesThe authors aimed to compare hospitalization and survival outcomes between patients with preserved and impaired RV-PA coupling.
methodsWe analyzed 1,059 patients with ventricular FMR who underwent M-TEER. RV-PA coupling was assessed after M-TEER using the ratio of tricuspid annular plane systolic excursion (TAPSE) to systolic pulmonary artery pressure (SPAP). Impaired RV-PA coupling was defined as TAPSE/SPAP <0.36 mm/mm Hg. The primary outcome was a composite of cardiovascular death and hospitalization for heart failure.
resultsOverall, 30.7% of patients exhibited impaired RV-PA coupling after M-TEER, with minimal improvement in TAPSE and SPAP. Patients with impaired RV-PA coupling at discharge had significantly lower event-free survival than those with preserved RV-PA (P = 0.004). Multivariate Cox regression analysis confirmed impaired RV-PA coupling as an independent predictor of the primary outcome (HR: 1.360; P = 0.029). The association between postprocedural RV-PA coupling and the primary outcome was more profound in patients with pulmonary hypertension (P = 0.047). Diabetes mellitus, impaired RV-PA coupling, lower left ventricular ejection fraction, smaller left ventricular size, and larger left atrial size before M-TEER were independent predictors of impaired RV-PA coupling.
conclusionsImpaired RV-PA coupling after M-TEER is independently associated with a higher risk of composite outcomes in patients with ventricular FMR, particularly those with pulmonary hypertension. Therefore, postprocedural assessment of RV-PA coupling may provide valuable prognostic insights and support risk stratification in this population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.