Evidence map›Paper›PMID 42246624›Full record

ArticleArchiv der Pharmazie2026

Structure-Activity Relationship Study on Ligands Activating the Voltage-Gated Potassium Channel K

Florian Roßner, Judith Schmidt, Guiscard Seebohm, Bernhard Wünsch

Abstract read
In one paragraph

Article in Archiv der Pharmazie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Florian RoßnerGRK 2515, Chemical Biology of Ion Channels (Chembion), Universität Münster, Münster, Germany.ORCID https://orcid.org/0009-0006-9117-4314
Judith SchmidtInstitute of Pharmaceutical and Medicinal Chemistry, University of Münster, Münster, Germany.
Guiscard SeebohmGRK 2515, Chemical Biology of Ion Channels (Chembion), Universität Münster, Münster, Germany.ORCID https://orcid.org/0000-0001-9303-5373
Bernhard WünschGRK 2515, Chemical Biology of Ion Channels (Chembion), Universität Münster, Münster, Germany.ORCID https://orcid.org/0000-0002-9030-8417

Funding

Deutsche Forschungsgemeinschaft
6 · The paper itself

Abstract

K

Indexed as

BenzodiazepinesKCNQ1 Potassium ChannelAnimalsDose-Response Relationship, DrugHumansLigandsMolecular StructureStereoisomerismStructure-Activity RelationshipBenzodiazepinesKCNQ1 Potassium ChannelLigands1,4‐benzodiazepin‐2‐onesactivationchiral HPLCKV7.1 ion channellipophilicitymetabolic stabilitypharmacokinetic parametersstructure–activity relationshipsSugasawa reactiontwo‐electrode voltage clamp

Identifiers

PMID42246624
PMCPMC13238819

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.