Evidence map›Paper›PMID 42246494›Full record

ArticleEmerging microbes & infections2026

Distinct cytotoxic cell subsets underlie protective and non-protective immunity to African swine fever virus.

David Marín-Moraleda, Aida Tort-Miró, Enrique Ezcurra, Sergio Montaner-Tarbes, Jordana Muñoz-Basagoiti, Elena Coatu, María Jesús Navas, Marta Muñoz, Paula Monleon, Judith González-Oliver and 5 more

Abstract read
In one paragraph

Article in Emerging microbes & infections, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

David Marín-MoraledaUnitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.ORCID 0009-0003-0919-231X
Aida Tort-MiróUnitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.ORCID 0009-0008-9284-0977
Enrique EzcurraUnitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.ORCID 0009-0001-3826-6299
Sergio Montaner-TarbesUnitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.ORCID 0000-0002-7664-3382
Jordana Muñoz-BasagoitiUnitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.ORCID 0000-0002-0384-5928
Elena CoatuUnitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.ORCID 0009-0006-1179-8128
María Jesús NavasUnitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.
Marta MuñozUnitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.
Paula MonleonUnitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.
Judith González-OliverUnitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.
Lola Pailler-GarcíaUnitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.ORCID 0000-0003-1211-7057
Sonia Pina-PedreroUnitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.ORCID 0000-0001-5475-4770
Francesc AccensiUnitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.ORCID 0000-0001-9068-0377
Fernando RodríguezUnitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.ORCID 0000-0001-7361-8408
Jordi ArgilaguetUnitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.ORCID 0000-0001-5924-2774

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Limited understanding of African swine fever (ASF) immunity remains a major barrier to the rational development of safe and effective vaccines. While antibody-mediated protection is still poorly defined, growing evidence highlights a central role for cellular immunity, particularly cytotoxic cells, as components associated with ASF virus (ASFV) infection control. However, the contribution of individual cytotoxic subsets across different virological and immunological contexts is not well characterized. Here, we investigated cytotoxic responses during BA71ΔCD2 live attenuated vaccine-induced protection and during late-stage lethal ASFV infection. Protective immunity was characterized by antigen-specific cytotoxic T-cell responses, whereas acute ASF was associated with broad cytotoxic activation. Early increases in perforin-positive CD4

Indexed as

African Swine FeverAfrican Swine Fever VirusT-Lymphocytes, CytotoxicAnimalsAntibodies, ViralImmunity, CellularInterferon-gammaPerforinSwineT-Lymphocyte SubsetsVaccines, AttenuatedViral VaccinesAntibodies, ViralInterferon-gammaPerforinVaccines, AttenuatedViral VaccinesAfrican swine feverASF immunitycorrelates of protectioncytotoxic cellslive attenuated vaccine

Identifiers

PMID42246494
PMCPMC13470925

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.