Evidence map›Paper›PMID 42246489›Full record

SynthesisHuman vaccines & immunotherapeutics2026

A systematic review on parental vaccine hesitancy for childhood immunizations in the European region: Can findings be generalized?

Toon Janssen, Julie Degraeve, Ilse De Coster, Ine Decuyper, Daan Van Brusselen, Stijn Verhulst

Abstract readSystematic Review
In one paragraph

Synthesis in Human vaccines & immunotherapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Toon JanssenLab of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium.ORCID 0009-0006-6570-4625
Julie DegraeveAntwerp Pediatric Clinical Trial Network, University of Antwerp, Antwerp, Belgium.ORCID 0000-0002-9971-4622
Ilse De CosterAntwerp Pediatric Clinical Trial Network, University of Antwerp, Antwerp, Belgium.ORCID 0000-0002-4847-2328
Ine DecuyperAntwerp Pediatric Clinical Trial Network, University of Antwerp, Antwerp, Belgium.ORCID 0000-0001-8127-5791
Daan Van BrusselenLab of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium.ORCID 0009-0007-1280-5980
Stijn VerhulstLab of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium.ORCID 0000-0002-1922-9716

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccine hesitancy (VH) for childhood immunizations has been widely studied, but no review has synthesized evidence across Europe. This review addresses that gap using both qualitative and quantitative perspectives. A systematic search on February 5th, 2025, was conducted in MEDLINE/PubMed and Web of Science to assess the generalizability of findings regarding parental VH regarding childhood vaccinations (excluding HPV and Influenza) across the WHO European Regions. Forty-nine articles published between January 2015 and December 2024 in English, Dutch or French were included. Using WHO's 3C model (confidence, convenience, complacency), trust in healthcare professionals (HCPs) emerged as a key factor, while fear of side effects, logistical barriers and low perceived disease risk negatively influenced decisions. Demographic determinants were not generalizable across countries due to methodological and contextual (cultural, socioeconomic and healthcare system) differences, reinforcing the need for tailored approaches. VH remains multidimensional and context-dependent. WHO's 3C model is a useful tool for understanding VH. Tailored, country-specific strategies are needed, with strong HCP - caregiver relationships and policies addressing practical and socioeconomic barriers to ensure equitable access to childhood vaccination.

Indexed as

ParentsPatient Acceptance of Health CareVaccinationVaccination HesitancyChildEuropeHealth Knowledge, Attitudes, PracticeHumansVaccinesVaccinesImmunizationvaccine acceptancevaccine hesitancyvaccine refusalvaccinology

Identifiers

PMID42246489
PMCPMC13245059

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.