Supramolecular Microcapsules via Microfluidic Interfacial Host-Guest Assembly: A Novel Strategy for Actives Encapsulation and Stimuli-Responsive Delivery.

Yuting Wu, Ningyuan Bai, Yuxin Chen, Ziang Xu, Bo Wang, Kai Liu, Yi Cheng

Abstract read

In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuting WuSinopec Beijing Research Institute of Chemical Industry, Beijing, China.

Ningyuan BaiDepartment of Chemical Engineering, Tsinghua University, Beijing, China.

Yuxin ChenDepartment of Chemical Engineering, Tsinghua University, Beijing, China.

Ziang XuDepartment of Chemical Engineering, Tsinghua University, Beijing, China.

Bo WangDepartment of Chemical Engineering, Tsinghua University, Beijing, China.

Kai LiuDepartment of Chemical Engineering, Tsinghua University, Beijing, China.ORCID https://orcid.org/0000-0003-3362-180X

Yi ChengDepartment of Chemical Engineering, Tsinghua University, Beijing, China.ORCID https://orcid.org/0000-0002-0711-1884

Funding

National Natural Science Foundation 21991104

6 · The paper itself

Abstract

The development of intelligent encapsulation systems that ensure both the stability and stimuli-responsive release of sensitive actives remains a critical challenge for personal care and pharmaceutical applications. This work presents a supramolecular strategy to fabricate intelligent microcapsules by integrating droplet microfluidics with host-guest chemistry. Specifically, phenylalanine-functionalized chitosan (CS-Phe) is designed to function as the guest polymer. Within the microfluidic system, positively charged CS-Phe is electrostatically anchored at the water-oil interface and dynamically crosslinked by cucurbit[8]uril (CB[8]), thereby forming monodisperse microcapsules with tunable sizes and shapes. These microcapsules exhibit high encapsulation stability and are dual-responsive to pH variations and competitive guests. This combination of properties establishes the resulting supramolecular microcapsules as a versatile platform for the intelligent encapsulation and on-demand release of active ingredients.

Indexed as

Drug Delivery SystemsMicrofluidicsBridged-Ring CompoundsCapsulesChitosanCucurbit(n)urilsHydrogen-Ion ConcentrationImidazolesMacrocyclic CompoundsPhenylalanineBridged-Ring CompoundsCapsulesChitosancucurbit(8)urilCucurbit(n)urilsImidazolesMacrocyclic CompoundsPhenylalaninecucurbit[8]urildroplet microfluidicsinterfacial self‐assemblysensitive activessupramolecular microcapsules

Identifiers

PMID42246451

DOI10.1002/smll.74077

PMCPMC13410440

What OpenQuestion holds

Textmetadata

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.