In one paragraphArticle in IUCrJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
21 authors.
Jos J A G KampsResearch Complex at Harwell, Rutherford Appleton Laboratory, Didcot OX11 0FA, United Kingdom.ORCID 0000-0001-8646-1796 Philip HinchliffeSchool of Biochemistry and Cellular and Molecular Medicine, University of Bristol, University Walk, Bristol, United Kingdom.ORCID 0000-0001-8611-4743 Johan GlerupDiamond Light Source, Harwell Science & Innovation Campus, Didcot OX11 0DE, United Kingdom.ORCID 0009-0005-3040-3817 Emily I FreemanDiamond Light Source, Harwell Science & Innovation Campus, Didcot OX11 0DE, United Kingdom.ORCID 0000-0003-1049-7674 Pauline A LangDepartment of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, United Kingdom.ORCID 0000-0003-3187-1469 Catherine L TookeDepartment of Life Sciences, University of Bath, Claverton Down, Bath BA2 7AX United Kingdom.ORCID 0000-0003-2180-3235 Michael BeerSchool of Biochemistry and Cellular and Molecular Medicine, University of Bristol, University Walk, Bristol, United Kingdom.ORCID 0000-0002-3879-3339 Laura ParkinsonSchool of Biochemistry and Cellular and Molecular Medicine, University of Bristol, University Walk, Bristol, United Kingdom.ORCID 0009-0009-5083-5018 Do Heon GuDiamond Light Source, Harwell Science & Innovation Campus, Didcot OX11 0DE, United Kingdom.ORCID 0000-0001-8777-0080 Sehan ParkPohang Accelerator Laboratory, Pohang University of Science and Technology, Pohang, Pohang 37673, Republic of Korea.
Nicholas DevenishDiamond Light Source, Harwell Science & Innovation Campus, Didcot OX11 0DE, United Kingdom.ORCID 0009-0000-3030-6180 Tiankun ZhouDiamond Light Source, Harwell Science & Innovation Campus, Didcot OX11 0DE, United Kingdom.ORCID 0000-0002-6116-7483 Anastasya ShilovaDiamond Light Source, Harwell Science & Innovation Campus, Didcot OX11 0DE, United Kingdom.ORCID 0000-0002-5931-5790 Samanpreet KaurDepartment of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, United Kingdom.
Patrick RabeDiamond Light Source, Harwell Science & Innovation Campus, Didcot OX11 0DE, United Kingdom.ORCID 0000-0002-3448-9559 Christopher J SchofieldDepartment of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, United Kingdom.ORCID 0000-0002-0290-6565 James SpencerSchool of Biochemistry and Cellular and Molecular Medicine, University of Bristol, University Walk, Bristol, United Kingdom.
Jaehyun ParkPohang Accelerator Laboratory, Pohang University of Science and Technology, Pohang, Pohang 37673, Republic of Korea.ORCID 0000-0002-9007-4892 Robin L OwenDiamond Light Source, Harwell Science & Innovation Campus, Didcot OX11 0DE, United Kingdom.ORCID 0000-0002-2104-7057 Allen M OrvilleDiamond Light Source, Harwell Science & Innovation Campus, Didcot OX11 0DE, United Kingdom.ORCID 0000-0002-7803-1777 Pierre AllerDiamond Light Source, Harwell Science & Innovation Campus, Didcot OX11 0DE, United Kingdom.ORCID 0000-0002-1793-7030 Funding
Biotechnology and Biological Sciences Research Council BB/T008741/1Biotechnology and Biological Sciences Research Council BB/T008784/1H2020 European Research Council 101021207Medical Research Council MR/T016035/1Medical Research Council UKRI330MRF_ BB/T008784/1MRF_ MRF-145-0004-TPG-AVISORoyal Society Wolfson Fellowship RSWF\R2\182017Wellcome Trust 227298/Z/23/ZWellcome Trust No. 210734/Z/18/Z
6 · The paper itselfAbstract
We describe the design and implementation of a drop-on-fixed-target method for time-resolved serial crystallography at both synchrotron and XFEL facilities. A piezoelectric droplet dispensing pipette is employed for addition of picolitre volume aqueous droplets (∼40-90 pl; ∼40-55 µm diameter sphere), containing (co-)substrate(s) or ligand(s), onto enzyme microcrystals previously loaded into the trapezoidal wells of an etched crystalline silicon fixed-target chip containing 25 600 wells in a high-density, square grid with 125 µm centre-to-centre well spacing. These features demand exquisite accuracy and thereby constrain motion controls to enable robust time-resolved crystallographic studies. The system was tested with three enzyme systems, comprising lysozyme and two β-lactamases, CTX-M-15 and AmpC
Indexed as
enzyme mechanismssample deliveryserial crystallographystructure determinationtime-resolved studies
Identifiers
PMID42246252
PMCPMC13324609
What OpenQuestion holds
Textmetadata
LicenceCC BY
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