Evidence map›Paper›PMID 42246187›Full record

RevieweLife2026

The NTR/prodrug revolution: Tools for controlling cell loss and regeneration.

Gha-Hyun J Kim, Michael Parsons

Abstract readReview
In one paragraph

Review in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Gha-Hyun J KimDepartment of Clinical Pharmacy Practice, UC Irvine School of Pharmacy and Pharmaceutical Sciences, Irvine, United States.ORCID https://orcid.org/0000-0001-9073-2034
Michael ParsonsDepartment of Developmental and Cell Biology, School of Biological Sciences, Natural Sciences II, University of California, Irvine, Irvine, United States.ORCID https://orcid.org/0000-0002-4046-1659

Funding

NIA NIH HHS NIA AG066519NIDDK NIH HHS DK080730
6 · The paper itself

Abstract

Here, we review the history, advancements, and broad utility of the NTR/prodrug system, and suggest future strategies for developing versatile ablation models. As a chemogenetic tool, the nitroreductase (NTR)/prodrug system enables precise spatiotemporal control over cell ablation. The technology leverages bacterial NTR enzymes (e.g.

Indexed as

NitroreductasesProdrugsRegenerationAnimalsChemogeneticsHumansNitroreductasesProdrugsdevelopmental biologydisease modelingnitroreductaseprodrug systemregenerationtargeted cell ablation

Identifiers

PMID42246187
PMCPMC13241088

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.