Article in Circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
10 authors.
Zizheng Tan *Shanghai Key Laboratory of Metabolic Remodeling and Health, State Key Laboratory of Genetics and Development of Complex Phenotypes, and Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China (Z.T., Y.C., Z.X., J.Z., L.L., H.W.).ORCID 0000-0001-7957-9091
Yue Qi *Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, China (Z.T., Y.Q., L.Z., C.L., B.L., H.W.).ORCID 0009-0008-8151-6231
Yujia ChenShanghai Key Laboratory of Metabolic Remodeling and Health, State Key Laboratory of Genetics and Development of Complex Phenotypes, and Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China (Z.T., Y.C., Z.X., J.Z., L.L., H.W.).
Liang ZhangObstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, China (Z.T., Y.Q., L.Z., C.L., B.L., H.W.).ORCID 0009-0001-5804-778X
Chao LiObstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, China (Z.T., Y.Q., L.Z., C.L., B.L., H.W.).
Bingkun LeiObstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, China (Z.T., Y.Q., L.Z., C.L., B.L., H.W.).
Ziqi XiaoShanghai Key Laboratory of Metabolic Remodeling and Health, State Key Laboratory of Genetics and Development of Complex Phenotypes, and Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China (Z.T., Y.C., Z.X., J.Z., L.L., H.W.).ORCID 0009-0000-9174-6243
Jingyan ZhangShanghai Key Laboratory of Metabolic Remodeling and Health, State Key Laboratory of Genetics and Development of Complex Phenotypes, and Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China (Z.T., Y.C., Z.X., J.Z., L.L., H.W.).ORCID 0009-0008-4624-1527
Lei LuShanghai Key Laboratory of Metabolic Remodeling and Health, State Key Laboratory of Genetics and Development of Complex Phenotypes, and Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China (Z.T., Y.C., Z.X., J.Z., L.L., H.W.).ORCID 0000-0002-1528-6123
Hongyan WangShanghai Key Laboratory of Metabolic Remodeling and Health, State Key Laboratory of Genetics and Development of Complex Phenotypes, and Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China (Z.T., Y.C., Z.X., J.Z., L.L., H.W.).ORCID 0000-0002-9422-5264
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
backgroundCongenital heart disease (CHD), the most common birth defect and a leading cause of infant mortality, is frequently linked to dysregulated Notch signaling. However, the role of the Notch transcriptional coactivator Mastermind-like 1 (MAML1) in CHD pathogenesis and the underlying molecular mechanism remain unclear.
methodsWe investigated the role of MAML1 in CHD by focusing on a patient-derived Q401K mutation with a knock-in mouse model and an endocardium-specific
resultsIn a clinical cohort of patients with CHD, we identified rare missense variants of
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Aberrant Phase Separation of Endothelial MAML1 Causes Congenital Heart Disease by Suppressing Notch Activity. · full record | OpenQuestion