Evidence map›Paper›PMID 42246006›Full record

ArticleFrontiers in cellular and infection microbiology2026

Bioinformatics identification of copyback and multihost-adapted defective viral genomes in dengue virus.

Jianhai Yu, Hao Wu, Yan Zhan, Yuan Liang, Linlin Xiang, Xuling Liu, Xiaoting Xie, Li Zhu, Qinghua Wu, Weiwei Xiao and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jianhai Yu *BSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.
Hao Wu *BSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.
Yan Zhan *BSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.
Yuan LiangBSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.
Linlin XiangBSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.
Xuling LiuBSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.
Xiaoting XieBSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.
Li ZhuBSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.
Qinghua WuBSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.
Weiwei XiaoBSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.
Chengsong WanBSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.
Chenguang ShenBSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.
Bao ZhangBSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.
Wei ZhaoBSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Defective viral genomes (DVGs) have been detected in clinical samples, and their antiviral effects have been verified. However, due to the limitations of traditional methods, all the reported DENV DVGs to date are Deletion DVGs, and it has not been proven that these DVGs can be stabilized across different hosts. Methods: We used the bioinformatics software DVGfinder with various dengue virus NGS data, including samples from patients, Results: First of all, we found copyback type DVGs in different datasets, with the dominant DVGs in patient sera being 3' copyback. Secondly, we observed that in C6/36 cells and Discussion: This study describes the distribution patterns of DVGs across different samples and provides preliminary bioinformatic evidence for a subset of deletion DVGs.

Indexed as

Computational BiologyDefective VirusesDengue VirusGenome, ViralAedesAnimalsCell LineChlorocebus aethiopsDengueHigh-Throughput Nucleotide SequencingHumansVero Cellscopyback DVGsdefective viral genomesdengue virusmultihost-adapted DVGsnext-generation sequencing

Identifiers

PMID42246006
PMCPMC13229894

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.