Evidence map›Paper›PMID 42245989›Full record

ArticleRSC advances2026

Native mass spectrometry reveals DltA catalysis, DltC loading, and inhibition in the d-alanylation pathway.

Yi Wang, Hannah Squires, Marian Aba Addo, Jospeh P Gerdt, Tarick J El-Baba, R Craig MacLean, Carol V Robinson, Jani R Bolla

Abstract read
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In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yi WangDepartment of Biochemistry, University of Oxford Oxford OX1 3QU UK jani.bolla@bioch.ox.ac.uk.
Hannah SquiresDepartment of Biochemistry, University of Oxford Oxford OX1 3QU UK jani.bolla@bioch.ox.ac.uk.
Marian Aba AddoDepartment of Chemistry, Indiana University Bloomington Indiana 47405-7012 USA.
Jospeh P GerdtDepartment of Chemistry, Indiana University Bloomington Indiana 47405-7012 USA.ORCID https://orcid.org/0000-0002-0375-4110
Tarick J El-BabaDepartment of Chemistry, University of Oxford Oxford OX1 3QZ UK.
R Craig MacLeanDepartment of Biology, University of Oxford Oxford OX1 3RB UK.
Carol V RobinsonDepartment of Chemistry, University of Oxford Oxford OX1 3QZ UK.
Jani R BollaDepartment of Biochemistry, University of Oxford Oxford OX1 3QU UK jani.bolla@bioch.ox.ac.uk.ORCID https://orcid.org/0000-0003-4346-182X

Funding

Elucidation of the first interspecies chemical signaling mechanisms in Capsaspora owczarzaki--the predator of a human pathogen and a model for the evolution of animal multicellularityR35GM138376 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI Joseph P. Gerdt · 2020 to 2026
$3.0M
NIGMS NIH HHS R35 GM138376
6 · The paper itself

Abstract

Gram-positive bacteria protect their cell envelope through d-alanylation of lipoteichoic acid (LTA), a process initiated by DltA-mediated activation of d-alanine and loading onto the carrier protein DltC. Although structural and biochemical studies have established key features of DltA catalysis, direct observation of adenylate formation and carrier protein loading within a reconstituted DltA-DltC system has remained limited. Here, we reconstituted the

Identifiers

PMID42245989
PMCPMC13231372

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.