Evidence map›Paper›PMID 42245950›Full record

Trial reportFrontiers in medicine2026

Determination of the 90% effective dose of propofol combined with oliceridine or fentanyl for inhibiting the insertion response in upper gastrointestinal endoscopy: a dose-finding trial.

Fangsheng Xu, Yuanyuan Cui, Ye Huang, Jian Tang, Yuan Xu, Mingcong Wang, Mengqi Liu, Kehui Qu, Jianfeng Pu, Meifang Wang and 1 more

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Fangsheng Xu *Department of Anesthesiology, Changshu No. 2 People's Hospital, Changshu, China.
Yuanyuan Cui *Department of Anesthesiology, Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, Changshu, China.
Ye HuangDepartment of Anesthesiology, Changshu No. 2 People's Hospital, Changshu, China.
Jian TangDepartment of Anesthesiology, Changshu No. 2 People's Hospital, Changshu, China.
Yuan XuDepartment of Anesthesiology, Changshu No. 2 People's Hospital, Changshu, China.
Mingcong WangDepartment of Anesthesiology, Changshu No. 2 People's Hospital, Changshu, China.
Mengqi LiuDepartment of Anesthesiology, Changshu No. 2 People's Hospital, Changshu, China.
Kehui QuDepartment of Anesthesiology, Changshu No. 2 People's Hospital, Changshu, China.
Jianfeng PuDepartment of Anesthesiology, Changshu No. 2 People's Hospital, Changshu, China.
Meifang WangDepartment of Anesthesiology, Changshu No. 2 People's Hospital, Changshu, China.
Qian WangDepartment of Anesthesiology, Changshu No. 2 People's Hospital, Changshu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Propofol combined with opioids is commonly used for procedural sedation, enhancing patient tolerance and reducing the incidence of adverse events. This study aimed to determine the 90% effective dose (ED Methods: This randomized, double-blind, dose-finding trial enrolled patients undergoing painless upper gastrointestinal endoscopy. Participants were assigned to receive propofol combined with fentanyl or oliceridine. A biased coin up-and-down sequential design was used to estimate the ED Results: A total of 115 patients were included in the final analysis (59 in Group F and 56 in Group O). The ED Conclusion: The ED Clinical Trial Registration: https://www.chictr.org.cn/, identifier ChiCTR2500096971.

Indexed as

biased coin designED90fentanyloliceridinepropofolupper gastrointestinal endoscopy

Identifiers

PMID42245950
PMCPMC13230018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.