ArticleFrontiers in medicine2026
Treg/Th17 imbalance and its association with frailty in elderly patients with community-acquired pneumonia.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the potential role of Treg/Th17 imbalance in frail elderly patients with community-acquired pneumonia (CAP) by analyzing the clinical characteristics of elderly CAP patients, along with the proportions of regulatory T (Treg) cells and helper T (Th17) cells 17, and related cytokine levels. Methods: A total of 61 hospitalized CAP patients aged ≥ 65 years were continuously enrolled from June 2021 to January 2022. Frailty status was assessed using the FRAIL scale, and patients were divided into a frail group ( Results: The frail group exhibited older age, more comorbidities, more severe illness, poorer prognosis, longer hospital stays, and higher treatment costs compared to the non-frail group. Additionally, the frail group had significantly higher proportions of Treg cells and Treg/Th17 ratios, as well as higher TGF-β levels and lower IL-17A levels ( Conclusion: Frail elderly CAP patients exhibit immune imbalance characterized by elevated Treg proportions and Treg/Th17 ratios, which may be associated with their poor prognosis and suggests potential value for immune-targeted interventions. The dysregulation of cytokines TGF-β and IL-17A aligns with the changes in Treg/Th17 proportions, potentially playing a role in the regulatory mechanisms of frailty-related immune imbalance.
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