Evidence map›Paper›PMID 42245920›Full record

ArticleRSC chemical biology2026

A two-step bioconjugation of

Jake Henry, Joe Nabarro, Harriet Chidwick, Georgia Conrich-Wilks, Emily G Morton-West, Alice Crook, Dave Boucher, Nathalie Signoret, Martin A Fascione

Abstract read
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In one paragraph

Article in RSC chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jake HenryDepartment of Chemistry, University of York York UK martin.fascione@york.ac.uk.
Joe NabarroDepartment of Chemistry, University of York York UK martin.fascione@york.ac.uk.ORCID https://orcid.org/0000-0003-0922-402X
Harriet ChidwickDepartment of Chemistry, University of York York UK martin.fascione@york.ac.uk.
Georgia Conrich-WilksDepartment of Biology University of York, Heslington York YO10 5DD UK.
Emily G Morton-WestDepartment of Chemistry, University of York York UK martin.fascione@york.ac.uk.
Alice CrookDepartment of Biology University of York, Heslington York YO10 5DD UK.
Dave BoucherDepartment of Biology University of York, Heslington York YO10 5DD UK.
Nathalie SignoretExperimental Medicine and Biomedicine Group, Hull York Medical School, University of York YO10 5DD UK nathalie.signoret@york.ac.uk.ORCID https://orcid.org/0000-0003-4977-4149
Martin A FascioneDepartment of Chemistry, University of York York UK martin.fascione@york.ac.uk.ORCID https://orcid.org/0000-0002-0066-4419

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipoteichoic acid (LTA), a major constituent of Gram-positive bacteria cell wall, is an amphiphilic glycolipid and well-established stimulator of immune cells through activation of Toll-Like Receptor 2 (TLR2) complexes. LTA binding to TLR2 is essential for this process but not the only step required, meaning that new tools are needed to visualize and track LTA interactions with host cells. Here we present a simple aldehyde-based bioconjugation approach to label native LTA purified from

Identifiers

PMID42245920
PMCPMC13231905

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.