Evidence map›Paper›PMID 42245913›Full record

Articlenpj health systems2026

A multi-agent large language model framework to automatically assess performance of a clinical AI Triage tool.

Adam E Flanders, Yifan Peng, Luciano Prevedello, Robyn Ball, Errol Colak, Prahlad Menon, George Shih, Hui-Ming Lin, Paras Lakhani

Abstract read
In one paragraph

Article in npj health systems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Adam E FlandersThomas Jefferson University, Philadelphia, PA, USA.
Yifan PengWeil-Cornell Medical Center, New York, NY, USA.
Luciano PrevedelloThe Ohio State University, Columbus, OH, USA.
Robyn BallThe Jackson Lab, Bar Harbor, Maine, USA.
Errol ColakUnity Health, Toronto, Canada.
Prahlad MenonThomas Jefferson University, Philadelphia, PA, USA.
George ShihWeil-Cornell Medical Center, New York, NY, USA.
Hui-Ming LinUnity Health, Toronto, Canada.
Paras LakhaniThomas Jefferson University, Philadelphia, PA, USA.

Funding

MEDICAL IMAGING AND DATA RESOURCE CENTER (MIDRC) YEAR 375N92020D00021 · NIBIB · UNIVERSITY OF CHICAGO · PI GIGER, MARYELLEN · 2021 to 2025
$16.6M
NHLBI NIH HHS 75N92020D00021
6 · The paper itself

Abstract

Radiology reports can be used as a surrogate for performance of clinical AI tools. Radiology reports were analyzed by an ensemble of eight open-source LLM models and a internal version of GPT-4o using a single multi-shot prompt that assessed for presence of ICH. Performance of the open-source models, consensus of models and GPT-4o were compared to human report review. Three ideal consensus LLM ensembles were tested for rating the performance of the triage tool. The capability of each LLM varied. The highest AUC performance was achieved with llama3.3:70b and GPT-4o. Using MCC the ideal combination of LLMs were: Full-9 Ensemble, Top-3 Ensemble and consensus. No statistically significant differences were observed between Top-3, Full-9, and consensus. An ensemble of open-source LLMs provides a more consistent and reliable method to derive a ground truth retrospective evaluation of a clinical AI triage tool over a single LLM alone.

Identifiers

PMID42245913
PMCPMC13233039

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.