ArticleCureus2026
Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Overlap Induced by Trimethoprim/Sulfamethoxazole: A Case Report.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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8 authors.
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Abstract
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) overlap is a rare, potentially life-threatening cutaneous hypersensitivity reaction that requires prompt recognition and appropriate treatment. Drug-induced hypersensitivity reactions are commonly associated with medications such as antimicrobials, anticonvulsants, and nonsteroidal anti-inflammatory drugs. This case report describes an 18-year-old female patient who was prescribed trimethoprim/sulfamethoxazole for asymptomatic bacteriuria in a primary care setting, despite the absence of a clear clinical indication, and subsequently developed SJS/TEN overlap with epidermal detachment involving 20% of the body surface area. The patient improved after withdrawal of the offending agent and intensive supportive management and was discharged after 22 days of hospitalization. This case highlights the importance of early diagnosis and immediate drug discontinuation to improve outcomes.
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