ArticleFrontiers in physiology2026
Dose-response to endurance training: a longitudinal study of training load and biomarkers in elite triathletes.
Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study examined the relationships between fatigue-related blood biomarkers, training load distribution, and performance changes in elite triathletes across a structured training season. Twenty athletes (11 international-level and 9 national-level) were monitored. Exercise stimuli were quantified using objective and subjective metrics during the general and specific preparatory periods, with each microcycle classified as heavy, moderate, or low according to accumulated weekly load. Baseline and follow-up blood samples were collected to assess urea and creatine kinase (CK), and an incremental cycling test with gas analysis was performed at the beginning and end of the training period to evaluate changes in physiological performance. Statistical analyses assessed pre-post differences, while correlation analyses explored associations between training load, biomarker responses, and performance outcomes. Urea concentrations increased significantly during severe (p < 0.001; ES: 2.1) and moderate (p < 0.001; ES: 1.2) load microcycles compared with baseline, whereas CK showed no meaningful associations across the season. Greater accumulated subjective training load was associated with larger increases in urea (ϱ = 0.67; p < 0.05), whereas a more favorable balance between the objectively monitored training load and the athlete's perceived exertion-characterized by lower perceived effort relative to the external load-was associated with smaller urea elevations (ϱ = -0.55; p<0.05). In addition, improvements in relative power at V̇O
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