Evidence map›Paper›PMID 42245802›Full record

ArticleResearch square2026

Adipocyte Enhancer Binding Protein 1 (AEBP1) Inhibition as a Potential Anti-Fibrotic Therapy in Heart Failure.

Thirupura Sundari Shankar, Joseph Visker, Junedh Amrute, Georgiy Polishchuk, Ty Lunde, Jing Ling, Peter Ferrin, Rana Hamouche, Dominik Feigle, Dallen Calder and 9 more

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Thirupura Sundari ShankarUniversity of Utah.ORCID 0000-0002-5009-2770
Joseph ViskerUniversity of Utah.ORCID 0000-0002-8490-6111
Junedh AmruteWashington University School of Medicine.ORCID 0000-0002-6851-0168
Georgiy PolishchukUniversity of Utah.
Ty LundeUniversity of Utah.
Jing LingUniversity of Utah.
Peter FerrinUniversity of Utah.ORCID 0009-0005-9006-2452
Rana HamoucheThe University of Utah.
Dominik FeigleFriedrich-Alexander University (FAU).
Dallen CalderUniversity of Utah.
Frank SachseUniversity of Utah.
Christos KyriakopoulosUniversity of Utah School of Medicine.ORCID 0000-0001-9415-1245
Eleni ManetaUniversity of Utah.
Eleni TseliouUniversity of Utah.
Sutip NavankasattusasUniversity of Utah.
Craig SelzmanUniversity of Utah.
Thomas SeidelFriedrich-Alexander University Erlangen-Nürnberg (FAU).ORCID 0000-0002-3127-1693
Kory LavineWashington University School of Medicine.ORCID 0000-0003-1948-9945
Stavros DrakosU Utah.ORCID 0000-0002-1223-327X

Funding

Deconstructing the diet-induced remodeling of adipose tissueR01DK134534 · NIDDK · BOSTON UNIVERSITY MEDICAL CAMPUS · PI STEPHEN ROBERT FARMER, MATTHEW D LAYNE · 2023 to 2026
$2.5M
Elucidating ACLP-dependent signaling pathways in the adipose tissue stromal-vascular nicheR01DK132080 · NIDDK · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LAYNE, MATTHEW D · 2022 to 2025
$2.0M
BLRD VA I01 BX006306NIDDK NIH HHS R01 DK132080NIDDK NIH HHS R01 DK134534
6 · The paper itself

Abstract

Persistent activation of cardiac fibroblasts into myofibroblasts drives excessive extracellular matrix deposition, leading to maladaptive myocardial fibrosis, adverse remodeling and heart failure (HF) progression. Adipocyte enhancer binding protein 1 (AEBP1) and Aortic carboxypeptidase-like protein (ACLP, full-length AEBP1 protein coded by

Identifiers

PMID42245802
PMCPMC13232471

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.