ArticleFrontiers in oncology2026
Case Report: A case of a pregnancy-associated breast cancer patient with a pathogenic variant in
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Pregnancy-associated breast cancer in patients with hereditary breast and ovarian cancer syndrome (HBOC) is relatively rare, and reports on treatment outcomes, including those involving risk-reducing surgery, remain limited. Case presentation: A 38-year-old woman at 8 weeks' gestation presented with a palpable mass in the left breast. Imaging revealed a tumor in the left breast, and further evaluation led to a diagnosis of luminal B-like, stage IIA left breast cancer. Her family history included a paternal cousin with pregnancy-associated breast cancer at age 37, a maternal grandmother with ovarian cancer at age 68, and a maternal grandaunt with breast cancer. Conclusions: Even in pregnancy-associated breast cancer complicated by HBOC, management should be individualized with careful consideration of safety, and the timing of each intervention should be determined according to the specific clinical circumstances of each patient.
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