ArticleFrontiers in immunology2026
Exploring glycerophospholipid metabolism in nasopharyngeal carcinoma: interactions between malignant epithelial cells and CCL11-expressing fibroblasts.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Nasopharyngeal carcinoma (NPC) is associated with aberrant cellular metabolism and interactions between tumor and stromal cells. This study aims to elucidate the role of glycerophospholipid metabolism in NPC, particularly focusing on the interplay between malignant epithelial cells and fibroblasts. Methods: We employed a multi-omics approach integrating single-cell transcriptomics, 10x spatial transcriptomics, and spatial metabolomics to analyze the gene expression and metabolite profiles in NPC tissues. Differential metabolite abundance and gene expression were evaluated to identify key glycerophospholipid-related genes. Results: We identified five glycerophospholipid-related genes-AGPAT3, DGAT2, SLC44A1, AGPAT5, and LPGAT1-that were significantly upregulated in NPC and EBER+ tumor-enriched regions. Fibroblasts expressing CCL11 were found to be associated with fatty acid accumulation and potentially with enhanced glycerophospholipid metabolism through interactions with malignant epithelial cells. Additionally, spatial trajectory analysis indicated shared and distinct gene expression patterns during differentiation toward peritumoral and intratumoral immune regions, revealing a complex landscape of NPC invasion. Conclusion: Our findings suggest that glycerophospholipid metabolism may play an important role in NPC progression and highlight the potential of AGPAT3, DGAT2, SLC44A1, AGPAT5, and LPGAT1 as diagnostic and prognostic markers. This study provides novel insights into the metabolic interactions within the NPC microenvironment, providing insights for potential targeted therapeutic interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.