SynthesisFrontiers in immunology2026
From mechanism to therapy: advances in macrophage polarisation and targeted intervention in osteosarcoma.
Synthesis in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Advances in the association between tumor immune microenvironment remodeling in osteosarcoma and the risk of pathological fractures.Frontiers in genetics · 2026Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteosarcoma is the most common type of primary malignant bone tumour in children and adolescents. Despite advances in surgery and neoadjuvant chemotherapy, tumour metastasis and recurrence are still the main factors affecting patient prognosis. Recent research has shown that immune cells in the tumour microenvironment (TME), particularly tumour-associated macrophages (TAMs), play a crucial role in osteosarcoma progression. Macrophages exhibit high plasticity and can differentiate into the M1 type, which has anti-tumour functions, or the M2 type, which promotes tumour development. This paper provides a systematic review of the research on TAMs and their mechanisms in promoting osteosarcoma progression by driving tumour cell proliferation, mediating immune evasion and facilitating metastasis and angiogenesis. Additionally, it provides a systematic outline of potential therapeutic strategies for inhibiting osteosarcoma development by targeting and regulating macrophage polarisation. These strategies include drug interventions, nanotechnology and combined immunotherapy. This paper aims to elucidate the key mechanisms by which macrophage polarisation regulates the biological behaviour of osteosarcoma. This will provide a theoretical basis and strategic references for the precise immunotherapy of osteosarcoma.
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