Evidence map›Paper›PMID 42245658›Full record

ArticleFrontiers in immunology2026

Family-wise resistance to infectious salmon anemia suggests that early systemic recognition protects against disease but not viral transcription.

Amber E Johnston, Deborah A Bouchard, Demitri Lifgren, Sarah M Turner, Daniel M DeLap, Mark P Polinski

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Amber E JohnstonAquatic Animal Health Laboratory, Aquaculture Research Institute, Cooperative Extension, University of Maine, Orono, ME, United States.
Deborah A BouchardAquatic Animal Health Laboratory, Aquaculture Research Institute, Cooperative Extension, University of Maine, Orono, ME, United States.
Demitri LifgrenNational Cold Water Marine Aquaculture Center, United States Department of Agriculture, Agricultural Research Service, Orono, ME, United States.
Sarah M TurnerAquatic Animal Health Laboratory, Aquaculture Research Institute, Cooperative Extension, University of Maine, Orono, ME, United States.
Daniel M DeLapAquatic Animal Health Laboratory, Aquaculture Research Institute, Cooperative Extension, University of Maine, Orono, ME, United States.
Mark P PolinskiNational Cold Water Marine Aquaculture Center, United States Department of Agriculture, Agricultural Research Service, Orono, ME, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Infectious salmon anemia virus (ISAV), the causative agent of infectious salmon anemia (ISA), is one of the most regulated pathogens affecting Atlantic salmon aquaculture globally. Recent investigations suggest a linkage between the host genome and ISA resistance, identifying a potential for promoting resistance through selective breeding. Herein, we sought to explore the dynamics associated with phenotypic ISA and/or ISAV resistance to better mitigate ISA disease. Methods: Forty families of North American Atlantic salmon were challenged with ISAV to determine family-wise survival, with fish from each family distributed across 16 tanks (one fish per family per tank) and exposed via injection ( Results: The most resistant ( Conclusions: Selective breeding for enhanced growth and sea lice resistance did not appear to incidentally impact family-wise resistance to ISA. Phenotypic ISA resistance was at least partially linked to differential gene expression patterns in the kidney, highlighting early upregulation of antiviral, inflammatory, and endothelial growth factors of resistant fish. However, disease (ISA) resistance was not associated with reduced ISAV transcripts, which showed prolonged high loads in the spleen of all families during infection. These data support early recognition of ISAV in kidney as important in disease mitigation, even when ISAV replication is systemic.

Indexed as

Disease ResistanceFish DiseasesIsavirusOrthomyxoviridae InfectionsSalmo salarAnimalsTranscription, GeneticViral LoadAtlantic salmondisease resistancegene expression pathwaysinfectious salmon anemia (ISA)ISAVphenotypic resistance

Identifiers

PMID42245658
PMCPMC13229969

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.