ReviewFrontiers in immunology2026
The mechanism of action and therapeutic potential of macrophages in osteoporosis: from polarization balance to targeted regulation.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Osteoporosis (OP) is a chronic metabolic bone disease characterised by low bone mass and deterioration of bone microarchitecture as its core pathological features, which predominantly affects the elderly population and postmenopausal women. Macrophages, as key components of the immune system, function in regulating inflammatory responses, tissue repair and immune modulation, and play a pivotal role in the pathogenesis and progression of osteoporosis: their distinct polarisation states can directly influence osteoblast differentiation and bone resorption activity, and the regulation of bone metabolic homeostasis mediated by macrophages has become one of the current research hotspots. Under specific stimuli, macrophages can polarise into the classically activated M1 phenotype with pro-inflammatory activity and the alternatively activated M2 phenotype with anti-inflammatory and reparative functions, and the imbalance in the M1/M2 polarisation ratio is one of the pathological factors contributing to the development and progression of osteoporosis (
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