ArticleFrontiers in nutrition2026
A novel nutritional index for predicting stroke-heart syndrome and clinical outcomes after endovascular treatment.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Metabolic-nutritional reserves influence stroke outcomes, but their role in large vessel occlusion acute ischemic stroke (LVO-AIS) treated with endovascular thrombectomy (EVT) remains unclear. We investigated whether the triglyceride-cholesterol-body weight index (TCBI) predicts dynamic myocardial injury after stroke and 90-day functional outcomes. Methods: This two-center retrospective cohort study included 524 anterior-circulation LVO-AIS patients undergoing EVT (2021-2024). TCBI was calculated as (triglycerides × total cholesterol × body weight)/1,000. Myocardial injury was classified using serial cardiac troponin I (cTnI) measurements into no injury, non-dynamic elevation, or dynamic elevation. The primary outcome was poor 90-day functional outcome (modified Rankin Scale [mRS] 3-6). Ordered logistic regression, restricted cubic splines, and the mediation analysis were performed. Results: A total of 524 patients were included. Low TCBI (≤1244) was associated with more severe myocardial injury (OR = 1.67, 95% CI: 1.13-2.47, Conclusion: Low TCBI was independently associated with stroke-induced myocardial injury and poor 90-day functional outcomes in LVO-AIS patients undergoing EVT, with myocardial injury serving as a potential mediator. These findings suggest that nutritional status may play a role in post-stroke cardiac and functional recovery, warranting further prospective investigation.
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