ArticleJournal of biomedical optics2026
Macrophage volume analysis and real-time monitoring by digital holography.
Article in Journal of biomedical optics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Sparse Cell Labeling Reveals Morphologic Diversity Among Mouse Scleral Fibroblasts.Investigative ophthalmology & visual science · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Significance: Cell volume serves as a macroscopic indicator of cellular metabolism, growth, and signal transduction. Understanding how cell volume varies across macrophage phenotypes is essential for interpreting their functional states and activation processes. Aim: We present a label-free, noninvasive method for 3D morphological characterization and volume quantification of macrophages and apply it to monitor volume variations during their biological behaviors. Approach: We employed a home-made off-axis digital holographic microscopy (DHM) system based on a Mach-Zehnder interferometric configuration to reconstruct the 3D morphology of cells. Using the mathematical relationship between the phase map and the cell thickness, we further calculated their cellular volume. Results: Our measurements show that M0 macrophages have a nearly spherical morphology with a volume of Conclusions: We demonstrate that DHM offers a powerful label-free strategy for quantifying macrophage volume and capturing the volume dynamic. It might be a potential approach for a macroscopic characterization to observe intracellular activities.
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