ArticleFrontiers in aging neuroscience2026
Resting-state EEG microstates link neural dynamics to fluid intelligence in mild cognitive impairment.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Resting-State EEG Microstate Dynamics as Neurophysiological Biomarkers Across the Alzheimer's Disease Continuum: A Systematic Review.Diagnostics (Basel, Switzerland) · 2026Review
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11 authors.
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Abstract
Background: Resting-state EEG microstates offer millisecond-scale markers of large-scale network dynamics that may capture early cognitive dysfunction in Mild Cognitive Impairment (MCI). We investigated whether microstate characteristics relate to global cognition and fluid intelligence in MCI. Methods: Sixty adults (30 MCI; 30 healthy controls, HC) were evaluated using the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and Raven's Progressive Matrices (RPM), and the Benton Facial Recognition Test (BFRT). Resting-state, eyes-closed EEG was recorded, and microstate Global Explained Variance (GEV) was calculated by mapping study specific topographies to the seven canonical classes (A-G) of the Metamaps2023 templates. In addition to GEV, temporal parameters (duration, occurrence, and coverage) were analyzed. Group differences and age/education/sex-adjusted correlations were assessed using a unified non-parametric framework with FDR correction. Results: MCI patients showed significantly lower scores across all cognitive domains compared to HC ( Conclusion: MCI is characterized by an increased contribution of microstates B and C, which are linked to impairments in fluid reasoning and executive control. These findings suggest that microstate dynamics serve as sensitive markers of early network disorganization in the predementia stage, reflecting a loss of neural flexibility that mirrors cognitive decline.
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