Evidence map›Paper›PMID 42245080›Full record

ArticleFrontiers in sports and active living2026

Chronotropic index mediates the relationship between lower-limb loss level and 6-minute walk test performance.

Samantha J Stauffer, Ryan T Pohlig, David G Edwards, Frank B Sarlo, John R Horne, Elisa S Arch, Jaclyn M Sions

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in sports and active living, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Samantha J StaufferDepartment of Physical Therapy, Delaware Limb Loss Studies, University of Delaware, STAR Campus, Newark, DE, United States.
Ryan T PohligBiostatistics Core, University of Delaware, Newark, DE, United States.
David G EdwardsDepartment of Kinesiology & Applied Physiology, University of Delaware, Newark, DE, United States.
Frank B SarloChristiana Spine Center, Newark, DE, United States.
John R HorneIndependence Prosthetics-Orthotics, Inc, Newark, DE, United States.
Elisa S ArchDepartment of Kinesiology & Applied Physiology, University of Delaware, Newark, DE, United States.
Jaclyn M SionsDepartment of Physical Therapy, Delaware Limb Loss Studies, University of Delaware, STAR Campus, Newark, DE, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Lower-limb loss (LLL) significantly impacts exercise capacity. Low heart rate, i.e., chronotropic, response to exercise is known to contribute to reduced exercise capacity in other clinical populations; associations between population-specific variables (e.g., LLL level), chronotropic response to activity, and exercise capacity among adults with LLL remain unknown. Methods: In this cross-sectional study, 130 community-dwelling adults with unilateral below-knee ( Discussion: Findings suggest chronotropic response may be a physiological contributor to reduced exercise capacity in adults with LLL. Thus, chronotropic index may be a critical target for improving exercise capacity in adults with unilateral LLL.

Indexed as

amputeescardiovascular deconditioningexercise testexercise toleranceheart ratewalk test

Identifiers

PMID42245080
PMCPMC13230178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.