Evidence map›Paper›PMID 42245071›Full record

ArticleRSC advances2026

Unlocking the antidiabetic potential of novel pyrazole-triazole hybrids through synthesis, dual α-amylase/α-glucosidase inhibition, multiscale biological evaluation, and molecular dynamics studies.

Mariam M Fakhry, Mahmoud S Elkotamy, Mohamed K Elgohary, Mahmoud Abdelrahman Alkabbani, Mayada H Mohamed, Abdulrahman A Almehizia, Ahmed M Naglah, Morkoss M Fakhry, Mohamed Fares, Hatem A Abdel-Aziz and 1 more

Abstract read
In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mariam M FakhryPharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian Russian University Badr Egypt Mariam-medhat@eru.edu.eg.ORCID https://orcid.org/0000-0002-1855-6918
Mahmoud S ElkotamyDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Alsalam University Kafr Alzayat 31611 Algharbia Egypt.ORCID https://orcid.org/0000-0002-8449-1788
Mohamed K ElgoharyPharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian Russian University Badr Egypt Mariam-medhat@eru.edu.eg.ORCID https://orcid.org/0000-0002-8269-9526
Mahmoud Abdelrahman AlkabbaniPharmacology and Toxicology Department, Faculty of Pharmacy, Egyptian Russian University Badr City Cairo 11829 Egypt.
Mayada H MohamedUniversity Family Medicine Center, Department of Family and Community Medicine, College of Medicine, King Saud University Medical City P.O. Box 2925 Riyadh 11472 Saudi Arabia.
Abdulrahman A AlmehiziaDrug Exploration and Development Chair (DEDC), Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University P.O. Box 2457 Riyadh 11451 Saudi Arabia anaglah@ksu.edu.sa.ORCID https://orcid.org/0000-0001-8711-3873
Ahmed M NaglahDrug Exploration and Development Chair (DEDC), Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University P.O. Box 2457 Riyadh 11451 Saudi Arabia anaglah@ksu.edu.sa.ORCID https://orcid.org/0000-0003-4377-5239
Morkoss M FakhryBiochemistry Department, Faculty of Pharmacy, Egyptian Russian University Badr City Cairo 11829 Egypt.
Mohamed FaresPharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian Russian University Badr Egypt Mariam-medhat@eru.edu.eg.
Hatem A Abdel-AzizApplied Organic Chemistry Department, National Research Center Dokki Cairo 12622 Egypt Hatem_741@yahoo.com.
Jalloul BouajilaLaboratoire de Génie Chimique, Université de Toulouse, Toulouse INP, CNRS, LGC Toulouse France jalloul.bouajila@univ-tlse3.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to design potent antidiabetic agents based on a pyrazole-linked carbohydrazide scaffold. Eighteen derivatives of substituted pyrazole-carbohydrazide linked to further pyrazole 8a-i or 1,2,3-triazolo-pyrazole 12a-i were synthesized. All synthesized compounds were evaluated for their inhibitory activity against α-amylase and α-glucosidase. Between them, compounds 8g, 12d, and 12e revealed potent inhibition for α-amylase (IC

Identifiers

PMID42245071
PMCPMC13231374

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.