Evidence map›Paper›PMID 42244990›Full record

ReviewTheranostics2026

Stimuli-responsive nanomaterials for wound healing: advances and emerging directions.

Yijia Dong, Yaqing Zhang, Junrong Wu, Yujun Yang, Yanli Zhang, Zhenjun Zhu, Rabiya Noor, Jawad Hussain, Longquan Shao, Yi Xing

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yijia DongStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, PR China.
Yaqing ZhangStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, PR China.
Junrong WuStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, PR China.
Yujun YangStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, PR China.
Yanli ZhangStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, PR China.
Zhenjun ZhuDepartment of Stomatology, Shenzhen People's Hospital, Shenzhen, 518020, PR China.
Rabiya NoorRiphah International University, Lahore, Pakistan.
Jawad HussainRiphah International University, Lahore, Pakistan.
Longquan ShaoStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, PR China.
Yi XingStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In wound healing applications, conventional nanomaterials fail to precisely regulate the wound healing process because of the lack of dynamic adaptation to the wound microenvironment. Conversely, stimuli-responsive nanomaterials can respond to endogenous stimuli such as pH, enzymes, reactive oxygen species (ROS), and glucose, as well as exogenous stimuli such as light, electricity, and magnetism. Thus, stimuli-responsive nanomaterials can facilitate precise drug delivery and effectively treat wounds, and some of these materials can even achieve integrated diagnosis and treatment. Previous reviews have focused mainly on hydrogel carriers with stimuli-responsive properties. This review focuses on stimuli-responsive nanomaterials, classifies these materials on the basis of their stimulus sources, and systematically summarizes the response mechanisms, application outcomes, and design strategies of endogenous, exogenous, and dual stimuli-responsive nanomaterials applied in wound healing. Furthermore, this review explores the research gaps and future developments of stimuli-responsive nanomaterials for wound healing.

Indexed as

Drug Delivery SystemsNanostructuresWound HealingAnimalsHumansHydrogelsHydrogen-Ion ConcentrationReactive Oxygen SpeciesHydrogelsReactive Oxygen Speciesdrug releaseintegrated diagnosis and treatmentmicroenvironmentstimuli-responsive nanomaterialswound healing

Identifiers

PMID42244990
PMCPMC13232620

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.