Evidence map›Paper›PMID 42244974›Full record

ArticleTheranostics2026

BMAL1 regulates tubular epithelial-derived exosomal miR-27a-3p to inhibit macrophage-myofibroblast transition and alleviate ischemia/reperfusion-induced renal fibrosis.

Wu Chen, Sheng Zhao, Songyuan Yang, Weimin Yu, Ting Rao, Xiangjun Zhou, Yuan Ruan, Fan Zou, Fan Cheng, Wei Li

Abstract read
In one paragraph

Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wu ChenDepartment of Urology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Sheng ZhaoDepartment of Urology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Songyuan YangDepartment of Urology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Weimin YuDepartment of Urology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Ting RaoDepartment of Urology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Xiangjun ZhouDepartment of Urology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Yuan RuanDepartment of Urology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Fan ZouDepartment of Urology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Fan ChengDepartment of Urology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Wei LiDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rationale: During ischemia‒reperfusion injury (IRI), Methods: A mouse model of kidney-specific Results: Renal IRI increased exosome secretion, promoted MMT, and exacerbated renal fibrosis, whereas Conclusions:

Indexed as

ARNTL Transcription FactorsExosomesKidney DiseasesMacrophagesMicroRNAsReperfusion InjuryAnimalsCell LineDisease Models, AnimalEpithelial CellsFibrosisKidneyKidney TubulesMaleMiceMice, Inbred C57BLARNTL Transcription FactorsBmal1 protein, mouseMicroRNAsMirn27 microRNA, mouseRab27a protein, mouserab27 GTP-Binding Proteinsbrain and muscle ARNT-like 1exosomesmacrophage-to-myofibroblast transitionrenal fibrosisrenal ischemia‒reperfusion injury

Identifiers

PMID42244974
PMCPMC13232619

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.